Quercetin 7-rhamnoside

Name: Quercetin 7-rhamnoside
Brand: Phytounique
Rating: 5 (1 reviews)

Catalogue No.： BP1189

CAS NO.: 22007-72-3

Purity: 98%

Brand: Phytounique

Botanical Source:

Quercetin is one of the most prominent dietary antioxidants, it is claimed to exert beneficial health effects, this includes protection against various diseases such as osteoporosis, certain forms of cancer, pulmonary and cardiovascular diseases but also against aging. It is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4±0.6 μM, 3.0±0.0 μM and 5.4±0.3 μM for PI3K γ, PI3K δ and PI3K β, respectively. It also attenuated the function VEGFR, androgen receptor and the expressions of NF-κB, IL Receptor, FAK, ERK,Nrf2. Quercetin 7-O-alpha-L-rhamnopyranoside is a quercetin O-glycoside that is quercetin attached to a alpha-L-rhamnopyranosyl moiety at position 7 via a glycosidic linkage. It has a role as a metabolite. It is an alpha-L-rhamnoside, a member of flavonols, a tetrahydroxyflavone, a monosaccharide derivative and a quercetin O-glycoside. It is functionally related to an alpha-L-rhamnopyranose.

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Related diseases

Atherosclerosis Alzheimer's Disease Type 2 Diabetes Mellitus Rheumatoid arthritis Liver Protection

Related targets

Atherosclerosis PIK3CG SIRT1 RELA TNF MMP9 PTGS2 NRF2 SOD1 CAT

Alzheimer's Disease BACE1 PIK3CG SIRT1 RELA TNF GSK3B ACHE MMP9 PTGS2 NRF2 SOD1 CAT GPX1

Type 2 Diabetes Mellitus PIK3CG SIRT1 MGAM RELA TNF GSK3B PTGS2 SOD1 CAT GPX1

Rheumatoid arthritis PIK3CG SIRT1 RELA TNF ACHE MMP9 PTGS2 SOD1

Liver Protection NRF2 SOD1 CAT GPX1 CYP2E1

Product description Related Products Prediction Parameters Reference Literature

Synonym name: Vincetoxicoside B; -Rhamnosylquercetin
Catalogue No.: BP1189
Cas No.: 22007-72-3
Formula: C₂₁H₂₀O₁₁
Mol Weight: 448.38
Botanical Source: Vincetoxicum officinale, Sedum caucasicum and other plant spp.

Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Can be supplied from milligrams to grams.

For Reference Standard and R&D, Not for Human Use Directly.
Inquire for bulk scale.

Description:

Vincetoxicoside B , quercetin, kaempferol , and (-)-epicatechin show synergistic antifungal activities with the FICI values <0.5.

References:

J Asian Nat Prod Res. 2017 Jan;19(1):47-52.

Chemical constituents from the rhizome of Polygonum paleaceum and their antifungal activity.

METHODS AND RESULTS:

A new compounds neopaleaceolactoside (1), along with nine known compounds phyllocoumarin (2), quercetin (3), quercitrin (4), quercetin-3-methyl ether (5), Vincetoxicoside B (6), isoquercitrin (7), kaempferol (8), (-)-epicatechin (9), and chlorogenic acid (10), was isolated from Polygonum paleaceum Wall. Their chemical structures were established based on one-dimensional and two-dimensional nuclear magnetic resonance techniques, mass spectrometry and by comparison with spectroscopic data reported. Some selected compounds were screened for their antifungal activity. Quercetin (3), Vincetoxicoside B (6), kaempferol (8), and (-)-epicatechin (9) showed synergistic antifungal activities with the FICI values <0.5.

CONCLUSIONS:

A preliminary structure-activity relationship could be observed that free 3-OH in the structure of flavonoids was important for synergistic antifungal activity.

HPLC of Quercetin 7-rhamnoside