Puerarin

Name: Puerarin
Brand: Biopurify
Rating: 5 (1 reviews)

Catalogue No.： BP1176

CAS NO.: 3681-99-0

Purity: 98%

Brand: Biopurify

Botanical Source: Puerariae lobatae radix

Puerarin is a hydroxyisoflavone that is isoflavone substituted by hydroxy groups at positions 7 and 4' and a beta-D-glucopyranosyl residue at position 8 via a C-glycosidic linkage. It has a role as an autophagy inducer, a ferroptosis inhibitor, an antioxidant, an antipyretic, an anti-inflammatory agent, a plant metabolite and a cardioprotective agent. It is a C-glycosyl compound and a hydroxyisoflavone. It is functionally related to an isoflavone. It is a conjugate acid of a puerarin(1-). Puerarin is a 5-HT2C receptor and benzodiazepine site antagonist, it exerts a regulatory effect on lipid accumulation by decreasing lipogenesis in hepatocytes, it may have therapeutic benefits in the treatment of fatty liver and lipid-related metabolic disorders, it also may act as an intracellular ROS scavenger, and its antioxidant properties may protect against Abeta25-35-induced cell injury,and apoptosis and could also promote the survival of PC12 cells.

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Related diseases

Myocardial ischemia

Related targets

Myocardial ischemia NOS3 ACE KCNH2 SLC8A1 ADRB1

Product description Related Products Prediction Parameters Reference Literature

Product name: Puerarin
Synonym name: 8-C-glucoside; 8-Glucopyranosyldaidzein; 8-Glucosyldaidzein
Catalogue No.: BP1176
Cas No.: 3681-99-0
Formula: C₂₁H₂₀O₉
Mol Weight: 416.382
Botanical Source: Pueraria spp
Physical Description: Powder
Type of Compound: Flavonoids

Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle

The product could be supplied from milligrams to grams, up to kilograms
Inquire for bulk scale.

Descriptions:
Puerarin is the most abundant of flavonoid derivatives in the root of Pueraria lobata (Willd) Ohwi, has antioxidant activity and can impair CYP-catalysed drug metabolism.[1]
Puerarin can reduce the atherogenic properties of dietary cholesterol in rats, the hypocholesterolemic function may be due to the promotion of cholesterol and bile acids excretion in liver. [2]
Puerarin could inhibit oxidative stress through the activation of phosphatidylinositol 3-kinase (PI3K)-Akt pathway, could significantly reduce traumatic brain injury (TBI)-induced neuronal degeneration, accompanied by the partial restoration of the redox disturbance and enhanced expression of phospho-Akt in the pericontusional cortex after TBI.[3]
Puerarin may act as an intracellular ROS scavenger, and its antioxidant properties may protect against Abeta25-35-induced cell injury,and apoptosis and could also promote the survival of PC12 cells.[4]
Puerarin can ameliorate Aβ(1-42)-induced and reverse the increase of in the hippocampus, the attenuation is associated with the activation of and of Bad, suggests that puerarin may be an anti-candidate drug to suppress both -related neuronal cell and dysfunction of the system.[5]

References:
[1] Guerra M C, Speroni E, Broccoli M, et al. Life Sci, 2000, 67(24):2997-3006.
[2] Yan L P, Chan S W, Chan S C, et al. Life Sci, 2006, 79(4):324-30.
[3] Wang J W, Wang H D, Cong Z X, et al. J Surg Res, 2014, 186(1):328-37.
[4] Hai-YingZhang, Yi-Heng Liu, Hong-Quan Wang, et al.Cell Biol Int,2008, 32(10):1230-7.
[5] Li J, Wang G, Liu J, et al. Eur J Pharm, 2010, 649(1-3):195–201.
[6] Peng Z B, Fan Y B, Tang W F. World Journal of Integrated Traditional & Western Medicine, 2009, 4(07):480-2.