Procyanidin B3

Name: Procyanidin B3
Brand: Phytounique
Rating: 5 (1 reviews)

Catalogue No.： BP1148

CAS NO.: 23567-23-9

Purity: 98%

Brand: Phytounique

Botanical Source: Grape Seed

Procyanidin B3(B3) is a procyanidin dimer that is widely studied due to its high abundance in the human diet and antioxidant activity. Procyanidin B3 is an inhibitor of histone acetyltransferase, B3 enhances the action of antagonist for prostate cancer cells via inhibition of p300-dependent acetylation of androgen receptor. Procyanidin B3 prevents osteoarthritis (OA) progression and heterotopic cartilage formation, at least in a part through the suppression of iNOS, these results support the potential therapeutic benefits of B3 for treatment of human OA and heterotopic ossification. Procyanidin B3 is a proanthocyanidin consisting of two molecules of (+)-catechin joined by a bond between positions 4 and 8' in alpha-configuration. It can be found in red wine, in barley, in beer, in peach or in Jatropha macrantha, the Huanarpo Macho. It has a role as an antioxidant, a metabolite, an anti-inflammatory agent and an EC 2.3.1.48 (histone acetyltransferase) inhibitor. It is a polyphenol, a proanthocyanidin, a biflavonoid and a hydroxyflavan.

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Related diseases

Antioxidant damage Prostate cancer Osteoarthritis Intervertebral Disc Degeneration Neurodegenerative Diseases (e.g., Alzheimer's Disease)

Related targets

Antioxidant damage NRF2 SOD1 CAT GPX1 HMOX1

Prostate cancer TLR4 BCL2 RELA TNF AR EP300 CASP3

Osteoarthritis TLR4 BCL2 RELA TNF NOS2 CASP3 IL1B HMOX1 MMP13 ACAN

Intervertebral Disc Degeneration TLR4 TNF NOS2 IL1B MMP13 ACAN

Neurodegenerative Diseases (e.g., Alzheimer's Disease) APP BCL2 RELA TNF NOS2 ACHE CASP3 IL1B NRF2 HMOX1 GFAP

Product description Related Products Prediction Parameters Reference Literature

Product name: Procyanidin B3
Synonym name: Proanthocyanidin B3
Catalogue No.: BP1148
Cas No.: 23567-23-9
Formula: C₃₀H₂₆O₁₂
Mol Weight: 578.526
Botanical Source: Occurs in Salix caprea and Fragaria spp. Present in red wine. peanut skins
Physical Description: Powder
Type of Compound: Procyanidins

Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle

Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.

The product could be supplied from milligrams to grams, up to kilograms
Inquire for bulk scale.

Descriptions:
Procyanidin B3 (B3) prevents osteoarthritis (OA) progression and heterotopic cartilage formation, at least in a part through the suppression of iNOS, these results support the potential therapeutic benefits of B3 for treatment of human OA and heterotopic ossification.[1]
Procyanidin B3 is an inhibitor of histone acetyltransferase, B3 enhances the action of antagonist for prostate cancer cells via inhibition of p300-dependent acetylation of androgen receptor; B3 treatment inhibited acetylation-dependent prostate cell proliferation and expression of cell-cycle control genes, subsequently increasing cell death, indicating the functional importance of AR acetylation for prostate cancer cell growth.[2]

References:
[1] Aini H, Ochi H, Iwata M, et al. Plos One, 2012, 7(5):e37728.
[2] Choi K C, Park S, Lim B J, et al. Biochem J, 2011, 433(1):235-44.
[3] Ricardo-Da-Silva J M, Bourzeix M, Cheynier V, et al. Vitis -Geilweilerhof-, 1991, 30(3):245-52.