Polygalaxanthone III

Name: Polygalaxanthone III
Brand: Biopurify
Rating: 5 (1 reviews)

Catalogue No.： BP1123

CAS NO.: 162857-78-5

Purity: 98%

Brand: Biopurify

Botanical Source: Polygalae radix

Polygalaxanthone III can significantly inhibit chlorzoxazone 6-hydroxylation catalyzed by CYP2E1.

View larger image

Catalog No	Package	Original Price	Price	Inventory	Quantity	Operating
BP1123-20mg	20mg	Sign in	Sign in
BP1123-100mg	100mg	Sign in	Sign in

Contacts：400-829-7929，028-82633860，82633397，82633165

After logging in, view the price and place an order

Consult Collect

Related diseases

Metabolic Syndrome Antitumor Neurodegenerative disease Alcoholic liver disease Drug-induced Liver Injury

Related targets

Metabolic Syndrome AMPK SIRT1 TNF PPARG NFKB1 CYP3A4

Antitumor BCL2 EGFR TP53 NFKB1 BAX CDKN1A

Neurodegenerative disease APP BCL2 AMPK SIRT1 TNF ACHE PPARG EGFR NFKB1 SNCA NRF2 CYP2E1 BAX

Alcoholic liver disease TNF PPARG NFKB1 NRF2 TGFB1 CYP2E1 BAX

Drug-induced Liver Injury BCL2 AMPK TNF TP53 NFKB1 CYP2E1 BAX CYP3A4

Product description Related Products Prediction Parameters Reference Literature

Synonym name:
Catalogue No.: BP1123
Cas No.: 162857-78-5
Formula: C₂₅H₂₈O₁₅
Mol Weight: 568.484
Botanical Source: Root of Polygala tenuifolia

Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Can be supplied from milligrams to grams.

For Reference Standard and R&D, Not for Human Use Directly.
Inquire for bulk scale.

Description:

Polygalaxanthone III can significantly inhibit chlorzoxazone 6-hydroxylation catalyzed by CYP2E1.

References:

Zhongguo Zhong Yao Za Zhi. 2014 Nov;39(22):4459-63.

[Effect of oligosaccharide esters and polygalaxanthone Ill from Polygala tenuifolia willd towards cytochrome P450].

METHODS AND RESULTS:

Five compounds (tenuifoliside C, tenuifoliside D, telephiose A, telephiose C and Polygalaxanthone III) from polygala tenuifolia wild were incubated together with CYP probe substrate in human liver microsomes to investigate the inhibitory effect towards CYP450 enzyme. Phenacetin (CYP1A2), coumarin (CYP2A6), paclitaxel (CYP2C8), diclofenac (CYP2C9), S-mepheriytoin (CYP2C19), dextromethorphan (CYP2D6), chlorzoxazone (CYP2E1), midazolam (CYP3A) were selected as the isoforfn specific substrate. And the formation of paracetamol, 7-hydroxycoumarin, 6alpha-hydroxy paclitaxel, 4'-hydroxydiclofenac, dextrorphan, 6-hydroxychlorzoxazone, 1'-hydroxymidazolam, 4'-hydroxymephenytoin were detected respectively to measure the effect towards CYP450 by high-pressure liquid chromatography (HPLC).

CONCLUSIONS:

The result shows that five compounds from polygala tenuifolia willd significantly inhibit chlorzoxazone 6-hydroxylation catalyzed by CYP2E1, while showed no effect towards CYP1A2, CYP2A6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP3A. And IC50 value was 38.73, 54.14, 61.77, 62.22, 50.56 micromol x L(-1), respectively.

HPLC of Polygalaxanthone III