Narirutin

Name: Narirutin
Brand: Phytopurify
Rating: 5 (1 reviews)

Catalogue No.： BP0985

CAS NO.: 14259-46-2

Purity: 98%

Brand: Phytopurify

Botanical Source: Aurantii fructus immaturus

Citrus narirutin fraction (CNF), contained 75% of narirutin, co-administration of CNF with alcohol can alleviate alcohol induced liver damage through preventing lipid formation, protecting antioxidant system and suppressing productions of pro-inflammatory cytokines. Narirutin has anti-inflammatory effect in a murine model of allergic eosinophilic airway inflammation, the mechanism is likely to be associated with a reduction in the OVA-induced increases of IL-4 and IgE. Narirutin is a disaccharide derivative that is (S)-naringenin substituted by a 6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage. It has a role as an antioxidant, a metabolite and an anti-inflammatory agent. It is a member of 4'-hydroxyflavanones, a (2S)-flavan-4-one, a rutinoside, a dihydroxyflavanone and a disaccharide derivative. It is functionally related to a (S)-naringenin.

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Related diseases

Metabolic disease Inflammatory disease Antiviral Oxidative Stress-Related Diseases Tuberculosis

Related targets

Metabolic disease STAT3 AMPK NFE2L2 MAPK1 TNF NOS2 PPARG NR1H3 SREBF1 PTGS2 NQO1 NFKB1 AKT1 IL6 IL1B IRS1 SLC2A4 FASN CPT1A INSR PPARA

Inflammatory disease STAT3 NFE2L2 MAPK1 TNF NOS2 PPARG PTGS2 NFKB1 AKT1 IL6 IL1B SOD1 HMOX1 PPARA

Antiviral NS3 NS5A NS5B E1 E2

Oxidative Stress-Related Diseases NFE2L2 MAPK1 PPARG NQO1 NFKB1 AKT1 SOD1 CAT GPX1 HMOX1 FOXO3 GSTP1 PPARA

Tuberculosis TNF NOS2 PTGS2 NFKB1

Product description Related Products Prediction Parameters Reference Literature

Product name: Narirutin
Synonym name: Naringenin-7-O-rutinoside; Isonaringin
Catalogue No.: BP0985
Cas No.: 14259-46-2
Formula: C₂₇H₃₂O₁₄
Mol Weight: 580.539
Botanical Source: Obt. from Camellia sinensis (tea)
Physical Description: Powder
Type of Compound: Flavonoids

Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle

Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.

The product could be supplied from milligrams to grams, up to kilograms
Inquire for bulk scale.

Descriptions:
Narirutin has anti-inflammatory effect in a murine model of allergic eosinophilic airway inflammation, the mechanism is likely to be associated with a reduction in the OVA-induced increases of IL-4 and IgE, suggests that narirutin may be an effective new tool in the treatment of bronchial asthma.[1]
Citrus narirutin fraction (CNF), contained 75% of narirutin, co-administration of CNF with alcohol can alleviate alcohol induced liver damage through preventing lipid formation, protecting antioxidant system and suppressing productions of pro-inflammatory cytokines.[2]
Narirutin has inhibition on cuprizone-induced apoptosis of oligodendrocyte.[3]

References:
[1] Funaguchi N, Ohno Y, Bu L B L, et al. Clin Exp Pharm P, 2007, 34(8):766-70.
[2] Park H Y, Sang K H, Eom H, et al. Food Chem Toxicol , 2013, 55(3):637-44.
[3] Zhan R, Watanabe K.. Neurosci Res, 2011, 71(3):e323.
[4] Lee S, Khoo C S, Pearson J L, et al. J Aoac Int, 2009, 92(3):789-96.