+86-28-82633987
Product name: Marmesin
Synonym name:
Catalogue No.: BP0924
Cas No.: 13849-08-6
Formula: C14H14O4
Mol Weight: 246.262
Botanical Source: Peucedanum decursivum.（Miq.）Maxim.
Physical Description:
Type of Compound: Coumarins
Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
The product could be supplied from milligrams to grams
Inquire for bulk scale.
Chengdu Biopurify Phytochemicals Ltd. is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine，TCM), Natural Active Pharmaceutical Ingredients worldwide.
The main services:
A. Supply active ingredients and reference standards of TCM, from mgs to kgs scale
B. Custom extraction and purification, target Herb Active Ingredients
C. Custom synthesis and semi-synthesis for Natural Active Ingredients
D. CR(contract research), CM(contract manufacture) and PD(process development) services from lab scale, pilot scale to commercial scale(GMP is also available)
E. TCM compounds library for drug screen,more than 3000 compounds available, many of them are rare and unique.
HPLC of Marmesin
Storage conditions：Short-term storage at 2~8℃, long-term storage at -20 ~ -80℃
59.6700
2.0735
2.0735
.0502
2.3050
9.1304
High
81.6143
3.1731
Yes
No
No
No
Yes
Yes
0.9
Yes
No
Yes
Yes
Marmesin is a natural compound with significant pharmacological activity, belonging to the furanocoumarins class and widely found in plants of the Apiaceae family. As the enantiomer of nodakenetin, Isopura Epiprolactone has attracted widespread attention in the field of natural product pharmacology in recent years due to its unique chemical structure and diverse bioactivity. Especially in research on the prevention and treatment of various tumors such as breast cancer, Isophyllis Eugenetolide has shown significant anti-cancer potential, involving multiple cellular signaling pathways and key molecular targets. This paper will systematically review the chemical structure and physicochemical properties of Lycosis scaberwolkulide, plant origin and extraction methods, pharmacological activity and mechanism, druggability evaluation, and pharmacokinetic characteristics, while exploring its clinical application prospects and future research directions.
The chemical name of Isoviola Meisterulolide is (+)-Isoviola Celastide, CAS number 13849-08-6, molecular formula C_13H_14O_5, and molecular weight 246.2620. Its structure belongs to the furanocoumarins class, with a core framework composed of coumarins fused with furan rings, exhibiting typical furanolide structural features. Isodakenetin is the enantiomeric of nodakenetin, and the two have spatial differences that may affect their biological activity and binding affinity to targets.
In terms of physicochemical properties, the LogP value of Isopuriflora prepegalolide is 2.0735, indicating moderate lipid solubility, which facilitates cell membrane penetration. Its topological polar surface area (TPSA) is 59.6700, suggesting that the molecule has certain polar groups that facilitate hydrogen bonding and other interactions with biological macromolecules. It has low water solubility (0.0502 mg/mL), indicating limited solubility in the aqueous phase, but this does facilitate oral absorption to some extent. The high blood-brain barrier penetration ability suggests that this compound may have pharmacological activity related to the central nervous system. The hERG channel inhibition test was negative, indicating a low risk of cardiotoxicity. The Ames trial scored 0.9, indicating a low genotoxicity risk and a solid safety foundation.
Eucalyptus dahurulide is mainly found in plants in the Apiaceae family, such as Peucedanum praeruptorum and Angelica dahurica, which are traditional Chinese medicinal herbs. These plants are often used in traditional Chinese medicine to dispel wind and relieve the exterior, relieve pain, and fight inflammation. As one of their active ingredients, Eudonoled, plays an important role in medicinal effects.
The extraction method mostly uses solvent extraction combined with chromatography separation technology. Traditional extraction mostly uses ethanol or methanol as solvents, and crude extracts are obtained through reflux extraction or ultrasound-assisted extraction. Subsequently, high-purity Isoviola pre-Potolide was obtained using silica gel column chromatography and reversed-phase high-performance liquid chromatography (RP-HPLC) for separation and purification. In recent years, supercritical fluid extraction and membrane separation technologies have also been applied to extract Phytolactone, improving extraction efficiency and purity.
During the extraction process, parameters such as temperature, solvent polarity, and extraction time significantly affect yield and purity. Optimizing the extraction process not only helps increase the yield of Phytolactone but also lays the foundation for large-scale production and drug development.
Rhizanolactone shows broad biological activity across various disease models, especially excelling in the antitumor field. Its main pharmacological activities include:
Anti-breast cancer effects
Breast cancer is one of the most common malignant tumors in women. Isopura Qiaoluolactone regulates the proliferation, apoptosis, migration, and invasion of breast cancer cells through multiple targets and pathways. In vitro cell experiments have shown that Lycodonolin can inhibit the proliferation of breast cancer cell lines (such as MCF-7 and MDA-MB-231), inducing cell cycle arrest and apoptosis. In animal models, Eucolactylolide significantly inhibited tumor growth and reduced metastatic potential.
Anti-inflammatory and antioxidant activities
Isopurpura pre-Hu lactone exhibits good anti-inflammatory and antioxidant effects by inhibiting the release of inflammatory mediators and regulating oxidative stress responses. This has potential value for regulating the tumor microenvironment and treating chronic inflammation-related diseases.
Neuroprotective effects
Due to its excellent blood-brain barrier penetration, Isoviola maoglutoin exhibits certain neuroprotective effects in neurodegenerative disease models, possibly by regulating oxidative stress and inflammatory responses.
Other potential activities
The study also found that the regulatory effect of Isopura sturerulolide on multidrug resistance-related proteins suggests its potential in overcoming tumor resistance.
The mechanism of action of Viola Phyllolide involves multiple signaling pathways and key molecular targets, mainly including:
AMPK（PRKAA1）
As regulators of cellular energy metabolism, AMPK activation helps inhibit metabolic reprogramming in tumor cells. Isopura Phyllalolide activates the AMPK signaling pathway, inhibiting the proliferation and migration of breast cancer cells.
BCL2（BCL2）
BCL2 family proteins regulate apoptosis, and Isophylla Eugenetis can downregulate the expression of the anti-apoptotic protein BCL2, promoting cancer cell apoptosis.
STAT3（STAT3）
The STAT3 signaling pathway plays a key role in tumor cell proliferation, survival, and immune evasion. Physicalolide inhibits STAT3 phosphorylation, blocks its transcriptional activity, and suppresses tumor growth.
ESR2（ESR2）
Estrogen receptor β (ERβ) has tumor-inhibiting effects in breast cancer. Viola sturpanolactone may influence hormone-dependent growth of breast cancer cells by regulating ESR2 expression.
ABCB1 and ABCG2 (ABCB1, ABCG2)
These two ATP-binding cassette transporters are closely associated with multidrug resistance in tumors. Isopura Phyllolide can inhibit the function of these two transport proteins, enhance intracellular accumulation of chemotherapy drugs, and overcome drug resistance.
PRKCA（PRKCA）
Protein kinase Cα plays an important role in cell signal transduction, and Isopura Eudontolactone regulates PRKCA activity, affecting cell proliferation and apoptosis.
MAPT（MAPT）
The microtubule-related protein Tau is involved in cytoskeletal stabilization, and the Isopura maprolactone may influence cell migration and invasion capacity by modulating MAPT.
MMP2（MMP2）
Matrix metalloproteinase 2 participates in the degradation of the extracellular matrix of tumors, promoting metastasis. Isopura pre-Hu lactone inhibits MMP2 activity and reduces tumor invasion.
LCK（LCK）
LCK is an Src family tyrosine kinase involved in immune regulation and tumor signaling. Isopura pre-Hu lactone influences the tumor immune microenvironment by modulating LCK signaling.
In summary, Lycogexinolide achieves comprehensive regulation of breast cancer cells through multi-target and multi-pathway synergistic effects, demonstrating strong anti-tumor potential.
The druggability parameters of Eucalyptus salide indicate that it has certain potential for drug development. The LogP is 2.0735, meeting the lipophilic requirements of the Lipinski rule, which is beneficial for oral absorption and cell membrane penetration. TPSA is 59.67, and moderate polarity helps bind to targets and improves bioavailability. Water solubility is relatively low, suggesting that solubility improvement strategies such as nanocarriers or solid dispersion technologies should be considered in formulation design.
High blood-brain barrier penetration suggests that Isophylla Cyptolactone may be used in the treatment of central nervous system diseases, but potential CNS toxicity is also warranted. hERG is inhibitively negative and Ames tests have low mutagenicity, indicating low cardiac safety and genotoxicity risk, providing safety assurance for clinical application.
Pharmacokinetics, there are few existing literature reports, but it is speculated that it may be metabolized in the liver in the body, mainly through oxidation and hydroxylation pathways. Due to its moderate lipid solubility, it has good oral absorption rates, but its bioavailability may be limited by the first-pass effect. In the future, further in vivo pharmacokinetic and toxicological studies are needed to clarify its absorption, distribution, metabolism, and excretion (ADME) characteristics.
As a natural furanocoumarin, Isoviola Phyllis shows broad clinical application prospects due to its multi-target anti-breast cancer activity. Its regulatory role in key molecular targets of breast cancer provides important lead compounds for the development of novel anticancer drugs. Especially in overcoming multidrug resistance and regulating the tumor microenvironment, Isoviola stureogolide has unique advantages.
Moreover, its excellent safety profile and blood-brain barrier penetration make it potentially valuable in the treatment of neurological diseases and inflammation-related conditions. In the future, combining modern drug design technologies, such as structural optimization, drug carrier system development, and targeted delivery strategies, it is expected to further enhance their efficacy and bioavailability.
However, clinical research on Isopura maohu lactone is still in its early stages and lacks systematic clinical trial data. In the future, pharmacokinetics, toxicology, and preclinical safety evaluations should be strengthened, with multi-center, multi-phase clinical trials conducted to verify clinical efficacy and safety.
As a natural product with a unique structure and diverse bioactivity, Isopura sturpanolactone has shown significant potential in therapeutic research against breast cancer and other diseases. Its multi-target and multi-mechanism mode of action provides rich scientific evidence for new drug development. Although there are still certain challenges in pharmacokinetics and clinical applications, supported by modern drug development technologies, Isopura Neo-Lycosis is expected to become an important candidate for future natural anticancer drugs. Future research should focus on in-depth analysis of its mechanism of action, optimization of druggability, and clinical translation, aiming to achieve its widespread clinical application.
Shenshuai
Wenjing
Hedandan
