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Kurarinone

BP3452
34981-26-5
98%
Phytopurify
Sophora flavescens Ait.
Kurarinone exhibits anti-tumor, estrogenic, and anti-inflammatory activities, it also shows strong inhibitory effect on immune responses. Kurarinone may ameliorate chronic inflammatory skin diseases through the suppression of pathogenic CD4(+) T-cell differentiation and the overall immune response. Kurarinone sensitizes TNF-related apoptosis inducing ligand (TRAIL)-induced tumor cell apoptosis via suppression of NF-κB-dependent cFLIP expression; it may be by way of down-regulating Smad3 expression to interfere its induction on intercellular signal transduction and consequently ameliorate renal interstitial fibrosis. (2S)-(-)-kurarinone is a trihydroxyflavanone that is (2S)-flavanone substituted by hydroxy groups at positions 7, 2' and 4', a lavandulyl group at position 8 and a methoxy group at position 5. Isolated from the roots of Sophora flavescens, it exhibits cytotoxicity against human myeloid leukemia HL-60 cells. It has a role as a metabolite and an antineoplastic agent. It is a member of 4'-hydroxyflavanones, a monomethoxyflavanone and a trihydroxyflavanone.
Kurarinone View larger image
Catalog No Package Original Price Price Inventory Quantity Operating
BP3452-10mg 10mg
BP3452-20mg 20mg
BP3452-100mg 100mg

Contacts：400-829-7929，028-82633860，82633397，82633165

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Chengdu Biopurify Phytochemicals Ltd.
Chengdu Biopurify Phytochemicals Ltd.

Related diseases

Rheumatoid arthritis Anti-inflammatory Psoriasis Non-small cell lung cancer Multiple Sclerosis

Related targets

BCL2 STAT3 TNF PIK3CA PTGS2 NFKB1 AKT1 IL6 IL1B IFNG IL17A STAT1
STAT3 TNF PTGS2 NFKB1 IL6 IL1B IL17A
STAT3 TNF PIK3CA EGFR PTGS2 NFKB1 AKT1 IL6 IL1B IFNG IL17A
BCL2 STAT3 TNF PIK3CA EGFR PTGS2 NFKB1 AKT1 IL6
BCL2 STAT3 TNF PTGS2 NFKB1 AKT1 IL6 IL1B IFNG IL17A
Product description Related Products Prediction Parameters Reference Literature

Product name: Kurarinone
Synonym name:
Catalogue No.: BP3452
Cas No.: 34981-26-5
Formula: C26H30O6
Mol Weight: 438.52
Botanical Source:
Physical Description: Cryst.
Type of Compound: Flavonoids

Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
The product could be supplied from milligrams to grams. Inquire for bulk scale.
We provide solution to improve the water-solubility of compounds, thereby facilitating the variety of activity tests and clinic uses.

For Reference Standard and R&D, Not for Human Use Directly.


Storage conditions：Short-term storage at 2~8℃, long-term storage at -20 ~ -80℃

Product drug property prediction parameters

  • 96.2200

  • 4.7891

  • 4.7613

  • .1274

  • 2.4570

  • 16.3175

  • Low

  • 90.3847

  • 3.9107

  • No

  • No

  • Yes

  • No

  • Yes

  • No

  • 0.0

  • Yes

  • No

  • Yes

  • No

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