Jaceosidin

Name: Jaceosidin
Brand: Phytopurify
Rating: 5 (1 reviews)

Catalogue No.： BP0806

CAS NO.: 18085-97-7

Purity: 98%

Brand: Phytopurify

Botanical Source: Artemisia argyi Levl.et Vant.

Typical COA MSDS

Jaceosidin has immunosuppressive, anti-oxidative, anti-inflammatory, and anticancer activities, it is also a microglial inhibitor with anti-neuroinflammation activity. Jaceosidin modulates the ERK/ATM/Chk1/2 pathway, leading to inactivation of the Cdc2-cyclin B1 complex, followed by G2/M cell cycle arrest in endometrial cancer cells. Jaceosidin inhibits T cell proliferation and activation, which is closely associated with its potent down-regulation of the IFN-γ/STAT1/T-bet signaling pathway. Jaceosidin is a trihydroxyflavone that is flavone with hydroxy groups at positions 5, 7 and 4' and methoxy groups at positions 3' and 6. Isolated from Salvia tomentosa and Artemisia asiatica, it exhibits anti-allergic, anti-inflammatory and apoptosis inducing activties. It has a role as a metabolite, an antineoplastic agent, an anti-allergic agent, an anti-inflammatory agent and an apoptosis inducer. It is a dimethoxyflavone and a trihydroxyflavone.

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BP0806-20mg	20mg	Sign in	Sign in
BP0806-100mg	100mg	Sign in	Sign in

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Related diseases

Inflammatory Bowel Disease Rheumatoid arthritis Antioxidant damage Breast cancer Colon cancer

Related targets

Inflammatory Bowel Disease TNF PTGS2 NFKB1 IL6 IL1B NRF2 SOD1 GPX1 HMOX1

Rheumatoid arthritis TNF PTGS2 NFKB1 IL6 IL1B SOD1 HMOX1

Antioxidant damage NRF2 SOD1 CAT GPX1 HMOX1

Breast cancer MCL1 PTGS2 NFKB1 HMOX1 BAX

Colon cancer MCL1 TNF PTGS2 NFKB1 BAX

Product description Related Products Prediction Parameters Reference Literature

Product name: Jaceosidin
Synonym name:
Catalogue No.: BP0806
Cas No.: 18085-97-7
Formula: C₁₇H₁₄O₇
Mol Weight: 330.292
Botanical Source: Centaurea arguta, Digitalis lanata, Artemisia arctica, Liatris chapmanii, Liatris gracilis, Helichrysum viscosum and others
Physical Description: Yellow powder
Type of Compound: Flavonoids

Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle

Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.

The product could be supplied from milligrams to grams, up to kilograms
Inquire for bulk scale.

Descriptions:
Jaceosidin and Eupatilin are bioactive flavones found in the medicinal herbs of the genus Artemisia, exhibit various antioxidant, antiinflammatory, antiallergic, and antitumor activities, jaceosidin is a competitive inhibitor of CYP1A2 with a K(i) value of 3.8 microM and a mixed-type inhibitor of CYP2C9 with K(i) value of 6.4 microM in human liver microsomes.[1]
Jaceosidin has anti-inflammatory effect, may reduce inflammation by inhibiting NF-kappaB activation.[2]
Jaceosidin has anticancer effect and antiproliferation effect , may be contributed by an induction of apoptosis involving cytochrome c release from mitochondria to cytosol, induces apoptosis in ras-transformed human breast epithelial cells through generation of reactive oxygen species.[3,4]
Jaceosidin exerts growth inhibitory effect by arresting the cells at G2/M phase and induction of apoptosis.[5]

References:
[1] Ji H Y, Kim S Y, Kim D K, et al. Molecules, 2010, 15(9):6466-75.
[2] Min S W, Kim NJBaek N I. J Ethnopharmacol, 2009, 125(3):497-500.
[3] Min‐Jung K, Do‐Hee K, Won L K, et al. Ann N Y Acad Sci, 2007, 1095(1):483-95.
[4] Lv W, Sheng X, Chen T, et al. J Biomed Biotechnol, 2008(1):394802.
[5] Khan M, Yu B, Rasul A, et al. Evid-based Compl Al, 2011, 2012(1):72-79.
[6] Zhou Q, Sun L L, Jiang B, et al. China Pharmacy, 2013, 24(47):4464-6.