Isoliquiritin

Name: Isoliquiritin
Brand: Biopurify
Rating: 5 (1 reviews)

Catalogue No.： BP0788

CAS NO.: 5041-81-6

Purity: 98%

Brand: Biopurify

Botanical Source: Glycyrrhiza Radix Et Rhizoma

Isoliquiritin is a monosaccharide derivative that is trans-chalcone substituted by hydroxy groups at positions 2' and 4' and a beta-D-glucopyranosyloxy group at position 4 respectively. It has a role as an antineoplastic agent and a plant metabolite. It is a beta-D-glucoside, a member of chalcones, a member of resorcinols and a monosaccharide derivative. It is functionally related to a trans-chalcone. Isoliquiritin has significant antidepressant-like, antifungal and anti-cancer activities. It induces apoptotic cell death through upregulating p53 and p21 in the A549 non-small cell lung cancer cells and inhibit the p53-dependent pathway and showed crosstalk between Akt activities.

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Product description Related Products Prediction Parameters Reference Literature

Product name: Isoliquiritin
Synonym name: Isoliquiritoside
Catalogue No.: BP0788
Cas No.: 5041-81-6
Formula: C₂₁H₂₂O₉
Mol Weight: 418.398
Botanical Source: Allium chinense (rakkyo), Glycyrrhiza glabra (licorice) and other Glycyrrhiza spp., Trifolium subterraneum and other spp.
Physical Description: Yellow powder
Type of Compound: Chalcones

Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle

Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.

The product could be supplied from milligrams to grams, up to kilograms
Inquire for bulk scale.

Descriptions:
Insampaedoksan is a traditional herbal medicine used for antipyretic and antiinflammatory diseases, isoliquiritigenin is the main compound of it , thus , isoliquiritigenin has bioactivity effects such as antioxidant, estrogenic and anticancer. [1]
Isoliquiritin, liquiritin,and isoliquirigenin are the active polyphenols present in Glycyrrhiza uralensis which has been used for the treatment of cancer and its complications, they induce apoptotic cell death through upregulating p53 and p21 in the A549 non-small cell lung cancer cells and inhibit the p53-dependent pathway and showed crosstalk between Akt activities,suggests they can be an alternative agent for the treatment of lung cancer.[2]
Isoliquiritin and liquiritin produce significant antidepressant-like effects, and their mechanism of action may be due to increased 5-HT and NE in the mouse hippocampus, hypothalamus and cortex.[3]
Isoliquiritin has antifungal activity, and has inhibitory effect against peronophythora litchi chen through a membrane damage mechanism, it may be used as a natural alternative to commercial fungicides or a lead compound to develop new fungicides for the control of litchi downy blight.[4]
Isoliquiritin has anti-tumor activity, can induce hepatoma cell apoptosis in H22-bearing mice by down-regulating the expression of Bcl-2 and up-regulating expression of Bax, Cyt-c and Caspase-3, it can also induce the apoptosis in MDA-MB-231 cells.[5]

References:
[1] Lee K J, Jung P M, Roh J H, et al. Asian J Chem, 2014,26(8):24-5.
[2] Zhou Y, Ho W S. Oncol Rep, 2014, 31(1):298-304.
[3] Wang W, Hu X, Zhao Z, et al. Prog Neuro-psychoph, 2008, 32(5):1179-84.
[4] Luo J, Li Z, Wang J, et al. Molecules, 2016, 21(2):237.
[5] Luo J, Li Z, Wang J, et al. Central South Pharmacy, 2015(08):806-10.
[6] Liu Y, Yang J S. China Pharm (English), 2005, 14(4):227-30.