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Synonym name:
Catalogue No.: BP0758
Cas No.: 56725-99-6
Formula: C27H30O11
Mol Weight: 530.526
Botanical Source: Epimedium grandiflorum and Epimedium macranthum
Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Can be supplied from milligrams to grams.
For Reference Standard and R&D, Not for Human Use Directly.
Inquire for bulk scale.
Description:
Icariside I is a metabolite product of Icariin.
References:
J Cell Physiol. 2013 Mar;228(3):513-21.
Functions and action mechanisms of flavonoids genistein and icariin in regulating bone remodeling.
METHODS AND RESULTS:
Icariin, a prenylated flavonol glycoside isolated from Epimedium herb, stimulates osteogenic differentiation of BMSCs and inhibits bone resorption activity of osteoclasts. Icariin, whose metabolites include Icariside I, Icariside II, icaritin, and desmethylicaritin, has no estrogenic activity. However, icariin is more potent than genistein in promoting osteogenic differentiation and maturation of osteoblasts. The existence of a prenyl group on C-8 of icariin molecular structure has been suggested to be the reason why icariin is more potent than genistein in osteogenic activity.
CONCLUSIONS:
Thus, the prenylflavonoids may represent a class of flavonoids with a higher osteogenic activity.
HPLC of Icariside I
HNMR of Icariside I
Storage conditions：Short-term storage at 2~8℃, long-term storage at -20 ~ -80℃
179.2800
1.6018
1.5396
.6693
.6011
.2542
Low
85.9195
4.1687
Yes
No
Yes
No
No
No
0.6
Yes
No
Yes
No
Shenshuai
Wenjing
Hedandan
