Ginsenoside Rg3

Name: Ginsenoside Rg3
Brand: Phytopurify
Rating: 5 (1 reviews)

Catalogue No.： BP0666

CAS NO.: 14197-60-5

Purity: 98%

Brand: Phytopurify

Botanical Source:

Ginsenoside Rg3 is the main component of Red ginseng, it inhibits Na+ and hKv1.4 channel with IC50s of 32.2±4.5 and 32.6±2.2 μM, respectively, it also inhibits Aβ levels, NF-κB activity, and COX-2 expression. Ginsenoside-Rg3 possesses an ability to inhibit the lung metastasis of tumor cells, and the mechanism of its antimetastatic effect is related to inhibition of the adhesion and invasion of tumor cells, and also to anti-angiogenesis activity. It is a novel drug, capable of inhibiting the early of scarring (HS) and later HS. (20S)-ginsenoside Rg3 is a ginsenoside found in Panax ginseng and Panax japonicus var. major that is dammarane which is substituted by hydroxy groups at the 3beta, 12beta and 20 pro-S positions, in which the hydroxy group at position 3 has been converted to the corresponding beta-D-glucopyranosyl-beta-D-glucopyranoside, and in which a double bond has been introduced at the 24-25 position.

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BP0666-20mg	20mg	Sign in	Sign in
BP0666-100mg	100mg	Sign in	Sign in
BP0666-1000mg	1000mg	Sign in	Sign in

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Related diseases

Hyperglycemia Atherosclerosis Alzheimer's Disease Cancer Myocardial Ischemia/Reperfusion Injury

Related targets

Hyperglycemia APP STAT3 SIRT1 PAX8 GPBAR1 GSK3B NPC1L1 NFKB1

Atherosclerosis BCL2 STAT3 SIRT1 TNF MMP9 NPC1L1 PTGS2 NFKB1 CASP3 VCAM1 VEGFA BAX

Alzheimer's Disease APP BCL2 STAT3 SIRT1 TNF GSK3B ACHE MMP9 PTGS2 NFKB1 CASP3 BAX

Cancer BCL2 STAT3 SIRT1 TNF MMP9 PTGS2 NFKB1 CASP3 VEGFA BAX

Myocardial Ischemia/Reperfusion Injury BCL2 SIRT1 TNF PTGS2 NFKB1 CASP3 BAX

Product description Related Products Prediction Parameters Reference Literature

Product name: Ginsenoside Rg3
Synonym name:
Catalogue No.: BP0666
Cas No.: 14197-60-5
Formula: C₄₂H₇₂O₁₃
Mol Weight: 785.025
Botanical Source: Panax spp.
Physical Description: White powder
Type of Compound: Triterpenoids

Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle

Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.

The product could be supplied from milligrams to grams, up to kilograms
Inquire for bulk scale.

Descriptions:
Ginsenoside-Rg3, possess an ability to inhibit the lung metastasis of tumor cells, and the mechanism of their antimetastatic effect is related to inhibition of the adhesion and invasion of tumor cells, and also to anti-angiogenesis activity.[1]
Ginsenoside-Rg3 (2.5 or 5.0 mg/kg body weight,s.c. injections) inhibits cancer metastasis through activities that do not affect the growth or vascularity of intestinal cancers.[2]
Ginsenoside Rg3 has anti-tumor property through its angiosuppressive activity, is a ginsenoside monomer with high anti-cancer activity.[3,4]
Ginsenoside-Rg3 has new pharmacological activity against testosterone-induced prostate overgrowth,downregulates AR by facilitating the degradation of AR protein, could be potential therapeutic regimens for treating BPH.[5]
Ginsenoside-Rg3 is a novel drug, capable of inhibiting the early of scarring (HS) and later HS. GS-Rg3/electrospun is a very promising new treatment for early and long-term treatment of HS.[6]

References:
[1] Mochizuki M, Yoo Y C, Matsuzawa K, et al. Biol Pharm Bull, 1995, 18(9):1197-202.
[2] Iishi H, Tatsuta M, Baba M, et al. Clin Exp Metastas , 1997, 15(6):603-11.
[3] Yue P Y K, Wong D Y L, Wu P K, et al. Biochem Pharmcol, 2006, 72(4):437-45.
[4] Xue-Long L I, Yao-Yao F U, Sun S Y, et al. Journal of Dalian Polytechnic University, 2010,29(6):396-8.
[5] Bae J S, Park H S, Park J W, et al. J Nat Med, 2012, 66(3):476-85.
[6] Cheng L, Sun X, Hu C, et al. Acta Biomater, 2013, 9(12):9461-73.
[7] Zhao Q, Zheng X, Jiang J, et al. J Chromatogr B , 2010, 878(24): 2266-73.