Ginsenoside Rc

Name: Ginsenoside Rc
Brand: Phytopurify
Rating: 5 (1 reviews)

Catalogue No.： BP0660

CAS NO.: 11021-14-0

Purity: 98%

Brand: Phytopurify

Botanical Source:

Ginsenoside Rc is a ginsenoside found in Panax ginseng that is dammarane which is substituted by hydroxy groups at the 3beta, 12beta and 20 pro-S positions, in which the hydroxy groups at positions 3 and 20 have been converted to the corresponding beta-D-glucopyranosyl-(12)-beta-D-glucopyranoside and alpha-L-arabinofuranosyl-(16)-beta-D-glucopyranoside respectively, and in which a double bond has been introduced at the 24-25 position. It has a role as a hypoglycemic agent and a plant metabolite. Ginsenoside Rc exhibits anti-diabetic, anti-adipogenic, anticancer and anti-inflammatory activities; it can attenuate inflammatory symptoms of gastritis, hepatitis and arthritis, and it can significantly enhance glucose uptake by inducing ROS generation, which leads to AMPK and p38 MAPK activation. Rc enhances GABA receptorA (GABAA)-mediated ion channel currents (IGABA), it also inhibits the expression of TNF-α and IL-1β.

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Related diseases

Metabolic Syndrome Inflammatory disease Neuroprotection Cancer Anxiety Disorders

Related targets

Metabolic Syndrome AMPK NFE2L2 RELA TNF PPARG IL1B INSR

Inflammatory disease NFE2L2 RELA TNF NOS2 PPARG MMP9 PTGS2 IL1B

Neuroprotection BACE1 BCL2 MAPT NFE2L2 CASP3 SNCA APOE PSEN1

Cancer BCL2 AMPK NFE2L2 RELA TNF NOS2 PPARG MMP9 PTGS2 CASP3

Anxiety Disorders TNF NOS2 PPARG IL1B

Product description Related Products Prediction Parameters Reference Literature

Product name: Ginsenoside Rc
Synonym name:
Catalogue No.: BP0660
Cas No.: 11021-14-0
Formula: C₅₃H₉₀O₂₂
Mol Weight: 1079.28
Botanical Source: Panax ginseng (ginseng)
Physical Description: White powder
Type of Compound: Triterpenoids

Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle

Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.

The product could be supplied from milligrams to grams, up to kilograms
Inquire for bulk scale.

Descriptions:
Ginsenoside Rc (Rc), a protopanaxadiol type ginsenoside, is the active component mainly responsible for the therapeutic and pharmacologic properties of ginseng, which are derived from its suppression of superoxide-induced free radicals, Rc can modulate Forkhead box O (FoxO1)phosphorylation through activation of PI3K/Akt and inhibition of AMPK and FoxO1 acetylation through interaction with CBP and SIRT1, and that this leads to upregulation of catalase under conditions of oxidative stress.[1]
Ginsenoside Rc from Korean Red Ginseng (Panax ginseng C.A. Meyer) exhibits anticancer and anti-inflammatory activities, can attenuate inflammatory symptoms of gastritis, hepatitis and arthritis.[2]
Ginsenoside Rc and Re induce c-fos in MCF-7 human breast carcinoma cells at both the mRNA and protein levels, they act via other transcription factors and not via estrogen receptor in c-Fos expression.[3]
Ginsenoside Rc significantly enhances glucose uptake by inducing ROS generation, which leads to AMPK and p38 MAPK activation.,consequently, it can be used as a potent natural anti-diabetic agent.[4]
Ginsenoside Rc can promote anti-adipogenic activity on 3T3-L1 adipocytes by down-regulating C/EBPα and PPARγ.[5]

References:
[1] Kim D H, Chan H P, Park D, et al. Arch Pharm Res, 2014, 37(6):813-20.
[2] Tao Y, Man H R, Lee J, et al. Am J Chinese Med, 2016:1-21.
[3] Lee Y J, Jin Y R, Lim W C, et al. Arch Pharm Res, 2003, 26(1):53-7.
[4] Lee M S, Hwang J T, Kim S H, et al. J Ethnopharmacol, 2010, 127(3):771-6.
[5] Yang J W, Kim S S. Molecules, 2015, 20(1):1293-303.
[6] Gao Y, Zang P, Hao J, et al. J Med Plants Res. 2012,6(15):3030-6.

NMR of Ginsenoside Rc