Genistin

Name: Genistin
Brand: Phytopurify
Rating: 5 (1 reviews)

Catalogue No.： BP0635

CAS NO.: 529-59-9

Purity: 98%

Brand: Phytopurify

Botanical Source: Glycine max

Supplementation of Genistin alone or with selenium provides antioxidant defense with high-potential chemopreventive activity against DMBA-induced mammary tumors more than selenium alone.Intravitreal injection of Genistin is safe and effective in reducing traumatic PVR in clinical treatment. Genistein 7-O-beta-D-glucoside is a 7-hydroxyisoflavones 7-O-beta-D-glucoside. It has a role as an anti-inflammatory agent, an apoptosis inducer and a cardioprotective agent. It is functionally related to a genistein. It is a conjugate acid of a genistein 7-O-beta-D-glucoside(1-).

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Related diseases

Type 2 Diabetes Mellitus Cardiovascular disease Obesity Breast cancer Anti-osteoporosis

Related targets

Type 2 Diabetes Mellitus PTPN1 NOS3 AMPK RELA MAPK1 PPARG PIK3CA PTGS2 IRS1 SLC2A4 FASN PPARD

Cardiovascular disease PTPN1 NOS3 BCL2 AMPK RELA MAPK1 PPARG PIK3CA ACE MMP9 PTGS2 FASN LDLR ICAM1 VEGFA LPL

Obesity PTPN1 AMPK MAPK1 PPARG PIK3CA IRS1 FASN PPARD LPL

Breast cancer PTPN1 BCL2 AMPK RELA MAPK1 ESR1 PPARG PIK3CA ACE MMP9 PTGS2 FASN CCND1 VEGFA

Anti-osteoporosis ESR1 MMP9 RUNX2 SP7 CTSK TNFRSF11B SOST

Product description Related Products Prediction Parameters Reference Literature

Product name: Genistin
Synonym name: Genistein 7-glucoside; Genistoside
Catalogue No.: BP0635
Cas No.: 529-59-9
Formula: C₂₁H₂₀O₁₀
Mol Weight: 432.381
Botanical Source: Genista spp., Lupinus spp. and a number of other spp. in the Leguminosae subfamily Papilionoideae. Also in wood of Prunus aequinoctalis, Prunus avium and Prunus nipponica
Physical Description: Powder
Type of Compound: Flavonoids

Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle

Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.

The product could be supplied from milligrams to grams, up to kilograms
Inquire for bulk scale.

Descriptions:
Genistin and daidzin are among the major isoflavonoids in soybeans and soy products,
genistin has antioxidant activity and anticarcinogenic properties, can inhibit UV light-induced plasmid DNA damage and cell growth in human melanoma cells.[1]
Genistein and genistin inhibit cell proliferation by disrupting the cell cycle, which is strongly associated with the arrest induction of either G1 or G2/M phase and may induce apoptosis, speculates that both genistein and genistin may prove useful as anticancer drugs and that the combination of genistein and genistin may have further anticancer activity.[2]
Dietary genistin can stimulate growth of estrogen-dependent breast cancer tumors similar to that observed with genistein.[3]
Genistin and daidzin have preventive effects on bone loss in ovariectomized rats fed a calcium-deficient diet.[4]

References:
[1] Russo A, Cardile V, Lombardo L, et al. J Nut Biochem, 2006, 17(2):103-8.
[2] Choi E J, Kim T, Lee M S. Life Sci, 2007, 80(15):1403-8.
[3] Allred C D, Ju Y H, Allred K F, et al. Carcinogenesis, 2001, 22(10):1667-73.
[4] Ishida H, Uesugi T, Hirai K, et al. Biol Pharml Bull, 1998, 21(1):62-6.
[5] Suo Z R, Qin H Y, Li-Cheng D U.Chinese J Pharm Anal, 2009,29(10):1662-4.