Galgravin

Name: Galgravin
Brand: Phytounique
Rating: 5 (1 reviews)

Catalogue No.： BP1793

CAS NO.: 528-63-2

Purity: 98%

Brand: Phytounique

Botanical Source:

Galgravin has anti-inflammatory, and neuroprotective effects, it can promote neuronal survival and neurite outgrowth, protect hippocampal neurons against amyloid beta peptide (Abeta25-35)-induced cytotoxicity, and protect against neuronal death from 1-methyl-4-phenylpyridinium ion (MPP+)-induced toxicity in cultured rat hippocampal neurons. Galgravin has cytotoxic activity against human leukemia (HL-60) tumor cells with the IC50 value of 16.5 ± 0.8 ug/mL. Galgravin also can inhibit bone resorption and may offer a novel compounds for the development of drugs to treat bone-destructive diseases such as osteoporosis. Galgravin is a member of the class of aryltetrahydrofurans carrying two 3,4-dimethoxyphenyl substituents at positions 2 and 5 as well as two methyl groups at positions 3 and 4. It has a role as a platelet aggregation inhibitor, a bone density conservation agent, a neuroprotective agent and a plant metabolite. It is a lignan, a ring assembly, an aryltetrahydrofuran and a dimethoxybenzene.

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Related diseases

Inflammatory Bowel Disease Rheumatoid arthritis Melanoma Glioma Acute Myeloid Leukemia

Related targets

Inflammatory Bowel Disease STAT3 RELA TNF NOS2 PTGS2 IL6 IL1B

Rheumatoid arthritis BCL2 STAT3 RELA TNF NOS2 PTGS2 CASP3 IL6 IL1B

Melanoma BCL2 STAT3 RELA TNF NOS2 PTGS2 TP53 CASP3 IL6 BRAF NRAS BAX CDKN1A

Glioma BCL2 STAT3 RELA TNF TP53 CASP3 BAX CDKN1A

Acute Myeloid Leukemia BCL2 STAT3 RELA TNF PTGS2 TP53 CASP3 BAX CDKN1A

Product description Related Products Prediction Parameters Reference Literature

Product name: Galgravin
Synonym name: (±)-Galgravin
Catalogue No.: BP1793
Cas No.: 528-63-2
Formula: C₂₂H₂₈O₅
Mol Weight: 372.461
Botanical Source: Flos Magnolia
Physical Description:
Type of Compound: Miscellaneous

Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
The product could be supplied from milligrams to grams. Inquire for bulk scale.
We provide solution to improve the water-solubility of compounds, thereby facilitating the variety of activity tests and clinic uses.

For Reference Standard and R&D, Not for Human Use Directly.