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Product name: Euscaphic acid
Synonym name: Euscophic acid; Jacarandic acid; 2alpha,3alpha,19alpha-Trihydroxyurs-12-en-28-oic acid
Catalogue No.: BP1819
Cas No.: 53155-25-2
Formula: C30H48O5
Mol Weight: 488.709
Botanical Source: Euscaphis japonica
Physical Description: Powder
Type of Compound: Triterpenoids
Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
The product could be supplied from milligrams to grams, up to kilograms
Inquire for bulk scale.
Descriptions:
Euscaphic acid, isolated from roots of Rosa rugosa, inhibits LPS-induced inflammatory responses by interference with the clustering of TRAF6 with IRAK1 and TAK1, resulting in blocking the activation of IKK and MAPKs signal transduction to downregulate NF-κB activations.[1]
Euscaphic acid and tormentic acid from the roots of Rosa rugosa have inhibitory effect on high fat diet-induced obesity in the rat.[2]
Euscaphic acid has anti-contraction effects on rat's aortic smooth muscle.[3]
References:
[1] In-Tae Kim ?, Suran Ryu ?, Ji-Sun Shin ?, et al. J Cell Biochem, 2012, 113(6):1936–46.
[2] Park H J, Nam J H, Jung H J, et al. Korean J Pharmacogn, 2005, 36(4):324-31.
[3] Mahmud S A. Adv Life Sci Technol, 2015, 33.
[4] Pan P, Jia L, Sun Q. Chinese J Pharm Anal, 2007, 27:841-3.
HPLC of Euscaphic acid
HNMR of Euscaphic acid
Storage conditions：Short-term storage at 2~8℃, long-term storage at -20 ~ -80℃
97.9900
4.4649
2.8414
.0097
1.8339
5.0133
Low
88.8252
5.0442
No
No
No
No
No
No
0.0
Yes
No
Yes
No
Shenshuai
Wenjing
Hedandan
