Digitoxin

Catalogue No.： BP0489

CAS NO.: 71-63-6

Purity: 98%

Brand: 普瑞法

The cardiac glycosides digitoxin and digoxin have been used in cardiac diseases for many years, digitoxin also has growth inhibition activity in three human cancer cell line, digitoxin activates pro-apoptotic, anti-proliferative signaling cascades and cell cycle arrest. Digitoxin could as a candidate drug for suppressing IL-8-dependent lung inflammation in cystic fibrosis (CF), it can suppress hypersecretion of IL-8 from cultured cystic fibrosis (CF) lung epithelial cells, the specific mechanism is to block phosphorylation of the inhibitor of NF-kappa.Digitoxin actively inhibits Herpes simplex virus type 1 (HSV-1) replication with a 50% effective concentration (EC(50)) of 0.05 microM, the inhibitory effects of digitoxin are likely to be introduced at the early stage of HSV-1 replication and the virus release stage. Digitoxin is a cardenolide glycoside in which the 3beta-hydroxy group of digitoxigenin carries a 2,6-dideoxy-beta-D-ribo-hexopyranosyl-(14)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(14)-2,6-dideoxy-beta-D-ribo-hexopyranosyl trisaccharide chain. It has a role as an EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor. It is functionally related to a digitoxigenin. It is a conjugate acid of a digitoxin(1-).

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Catalog No	Package	Original Price	Price	Inventory	Quantity	Operating
BP0489-20mg	20mg	Sign in	Sign in
BP0489-100mg	100mg	Sign in	Sign in

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Related diseases

Heart Failure Breast cancer Non-small cell lung cancer Multiple Sclerosis Influenza Virus Infection

Related targets

Heart Failure BCL2 MAPK1 ESR1 TNF NFKB1 CACNA1C ATP1A1 SLC8A1 KCNJ2 RYR2

Breast cancer BCL2 STAT3 MAPK1 ESR1 TP53 NFKB1 CASP3 CACNA1C ATP1A1 Cyclin B1

Non-small cell lung cancer BCL2 STAT3 MAPK1 TNF TP53 NFKB1 CASP3 IL6 ATP1A1 Cyclin B1

Multiple Sclerosis BCL2 STAT3 MAPK1 TNF NFKB1 IL6 ATP1A1 IFNG IL17A

Influenza Virus Infection STAT3 TNF NFKB1 IL6

Product description Related Products Prediction Parameters Reference Literature

Synonym name: Cardidigin; Crystodigin; Digisidin; Purodigin; Unidigin; Digitrin; Carditoxin
Catalogue No.: BP0489
Cas No.: 71-63-6
Formula: C₄₁H₆₄O₁₃
Mol Weight: 764.95
Botanical Source: From Digitalis purpurea, Digitalis lanata, Digitalis grandiflora, Digitalis ferruginea, Digitalis thapsi, Digitalis ciliata, Digitalis heywoodii and others

Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Can be supplied from milligrams to grams.

For Reference Standard and R&D, Not for Human Use Directly.
Inquire for bulk scale.