Dehydrocostus Lactone

Name: Dehydrocostus Lactone
Brand: Phytopurify
Rating: 5 (1 reviews)

Catalogue No.： BP0461

CAS NO.: 477-43-0

Purity: 98%

Brand: Phytopurify

Botanical Source: Aucklandia lappa Decne.

Dehydrocostus lactone (DHE), a natural sesquiterpene lactone, inhibits IKKβ, Wnt/β-catenin activity, IκBα phosphorylation and degradation, coactivators p300 recruitments and p50/p65 NF-κB nuclear translocation, and their DNA binding activity on COX-2 promoter. DHE has anti-inflammatory, antioxidant, anti-ulcer, immunomodulatory and anti-tumor properties, it can against osteoblast damage induced by AMA and cervical cancer. DHE exhibits strong larvicidal activity against A. albopictus with LC(50) values of 2.34 ug/ml. Dehydrocostus lactone is an organic heterotricyclic compound and guaianolide sesquiterpene lactone that is acrylic acid which is substituted at position 2 by a 4-hydroxy-3,8-bis(methylene)decahydoazulen-5-yl group and in which the hydroxy group and the carboxy group have undergone formal condensation to afford the corresponding gamma-lactone.

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Related diseases

Autoimmune disease Anti-inflammatory Cancer Neurodegenerative disease Metabolic Syndrome / Type 2 Diabetes

Related targets

Autoimmune disease BCL2 STAT3 [object TNF MMP9 PTGS2 NFKB1 IL6 IL1B FOXP3 IFNG IL17A

Anti-inflammatory STAT3 TNF PTGS2 NFKB1 IL6 IL1B IL17A

Cancer BCL2 STAT3 AMPK NFE2L2 HIF1A TNF PPARG MMP9 PTGS2 NFKB1 CASP3 HMOX1 CCND1

Neurodegenerative disease APP BCL2 STAT3 AMPK [object NFE2L2 TNF PPARG PTGS2 NFKB1 CASP3 SNCA IL6 IL1B HMOX1 CCND1

Metabolic Syndrome / Type 2 Diabetes AMPK PPARG IRS1 SLC2A4

Product description Related Products Prediction Parameters Reference Literature

Product name: Dehydrocostus Lactone
Synonym name: Epiligulyl oxide
Catalogue No.: BP0461
Cas No.: 477-43-0
Formula: C₁₅H₁₈O₂
Mol Weight: 230.307
Botanical Source: Saussurea lappa, Veronica hirsuta and Zaluzania tribolia
Physical Description: Powder
Type of Compound: Sesquiterpenoids

Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle

Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.

The product could be supplied from milligrams to grams, up to kilograms
Inquire for bulk scale.

Descriptions:
Dehydrocostus lactone(DCL) is exuded from sunflower roots and low DCL concentrations stimulate germination of the root parasite Orobanche cumana.[1]
Dehydrocostus lactone(0.1-10microg/ml) can protect osteoblasts against H(2)O(2)
-induced cellular dysfunction, may be valuable as a protective agent against oxidative damage in osteoblasts.[2]
Dehydrocostus lactone increases cellular resistance to oxidant injury in HepG2 cells, may via causing the nuclear accumulation of the nuclear factor E2-related factor 2 (Nrf2) and increasing the promoter activity of antioxidant response element (ARE).[3]
Dehydrocostus lactone and costunolide exhibits strong larvicidal activity against A. albopictus with LC(50) values of 2.34 and 3.26 ug/ml, respectively, while the essential oil had an LC(50) value of 12.41 ug/ml. [4]

References:
[1] El-Nadi M, Zohni O. Phytochemistry, 2011, 72(7):624-34.
[2] Choi E M, Kim G H, Yong S L. Toxicol In Vitro, 2009, 23(5):862-7.
[3] Jeong G S, Pae H O, Jeong S O, et al. Eur J Phamarmacol, 2007, 565(565):37-44.
[4] Zhi L L, He Q, Sha S C, et al. Parasitol Res?, 2011, 110(6):2125-30.
[5] Tan S J, Qiu D, Liu G, et al. Chinese Journal of Pharmaceutical Analysis, 2011, 31(1):145-7.