Daidzein

Name: Daidzein
Brand: Biopurify
Rating: 5 (1 reviews)

Catalogue No.： BP0445

CAS NO.: 486-66-8

Purity: 98%

Brand: Biopurify

Botanical Source: Glycine max

Daidzein is a member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone substituted by an additional hydroxy group at position 4'. It has a role as an EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor, an antineoplastic agent, an EC 3.2.1.20 (alpha-glucosidase) inhibitor, a plant metabolite and a phytoestrogen. It is a conjugate acid of a daidzein(1-). Daidzein is a natural isoflavone phytoestrogen and a PPAR activator, used as a component of foods and dietary supplements, it should be a promising feed additive for production of high-quality beef meat. Daidzein has antitumor, anti-fibrotic, anti-bone loss, and anti-inflammatory effects. Daidzein inhibits TLR4-MyD88-NF-κB pathway.

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Catalog No	Package	Original Price	Price	Inventory	Quantity	Operating
BP0445-100mg	100mg	Sign in	Sign in
BP0445-1000mg	1000mg	Sign in	Sign in

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Related diseases

Type 2 Diabetes Mellitus Cardiovascular disease Osteoporosis Menopausal syndrome Cancer

Related targets

Type 2 Diabetes Mellitus NOS3 AMPK MGAM GSK3B PPARG NFKB1 AKT1 SLC2A4 INSR PPARA

Cardiovascular disease NOS3 BCL2 AMPK ESR2 PPARG ACE MMP9 NFKB1 AKT1 CTNNB1 LDLR VCAM1 VEGFA PPARA

Osteoporosis NOS3 BCL2 AMPK ESR2 ESR1 CYP19A1 GSK3B PPARG MMP9 NFKB1 AKT1 CTNNB1 VEGFA TNFRSF11B PPARA BMP2

Menopausal syndrome ESR2 ESR1 CYP19A1 NFKB1 FSHR LHB NR5A1

Cancer BCL2 AMPK ESR2 TOP2A CYP19A1 PPARG MMP9 NFKB1 AKT1 CDK2 CTNNB1 VEGFA TIMP1

Product description Related Products Prediction Parameters Reference Literature

Product name: Daidzein
Synonym name:
Catalogue No.: BP0445
Cas No.: 486-66-8
Formula: C₁₅H₁₀O₄
Mol Weight: 254.241
Botanical Source: Widespread isoflavone in the Leguminosae (Papilionoideae) e.g. in Chamaecytisus spp., Cytisus spp., Phaseolus spp. Also from Streptomyces xanthophaeus and Streptoverticillium album
Physical Description: Yellow powder
Type of Compound: Flavonoids

Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle

Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.

The product could be supplied from milligrams to grams, up to kilograms
Inquire for bulk scale.

Descriptions:
Daidzein and genistein glucuronides (DG and GG), major isoflavone metabolites, may be partly responsible for biological effects of isoflavones, such as estrogen receptor binding and natural killer cell (NK) activation or inhibition; DG and GG are weakly estrogenic, and they activate human NK cells in nutritionally relevant concentrations in vitro, probably at a site different from IL-2 action.[1]
Daidzein, genistein, and their .beta.-glycoside conjugates can inhibit mammary tumorigenesis in animal models of breast cancer, may have antitumor activity against breast cancer.[2]
Daidzein and daidzin can suppress free-choice ethanol intake by Syrian golden hamsters.[3]
Daidzein or 17 alpha-ethinylestradiol is more efficient than genistein in preventing ovariectomy-induced bone loss in rats.[4]

References:
[1] Zhang Y, Song T T, Cunnick J E, et al. J Nut, 1999, 129(2):399-405.
[2] Coward L, Barnes N C, Setchell K D R, et al. J Agr Food Chem, 1993, 41(11):1961-7.
[3] Keung W M, Vallee B L. P Nat Acad Sci USA, 1993, 90(21):10008-12.
[4] Picherit C, Coxam V, Bennetau-Pelissero C, et al. J Nut, 2000, 130(7):1675-81.
[5] Zhao X, Shen Q, Ma Y. J Chromatogr B, 2011, 879(1):113-6.