Product name: Cucurbitacin A
Synonym name: Cucurbitacin A
Catalogue No.: BPF0324
Cas No.: 6040-19-3
Formula: C
32H
46O
9Mol Weight: 574.711
Botanical Source: Physical Description: Powder
Type of Compound: Triterpenoids
Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
The product could be supplied from milligrams to grams, up to kilograms
Inquire for bulk scale.
Descriptions:Cucurbitacin A inhibits cancer growth in A-549 NSCLC cells by inducing apoptosis, targeting m-TOR/PI3K/Akt signalling pathway and G2/M cell cycle.
Cucurbitacin A induced dose-dependent cytotoxic effects along with suppressing the colony forming tendency in these cells. Cucurbitacin A also induced morphological changes in these cells featuring chromatin condensation, cell shrinkage and apoptotic body formation. G2/M phase cell cycle collapse was also induced by Cucurbitacin A along with inhibition of expression levels of m-TOR/PI3K/Akt proteins.
References:[1] Hassoun M S, Clement M J, Hamdi I, et al. Biochem Pharmacol, 2015, 102:45-63.
[2] Peng Z X, Cao M, Zhang Y J, et al. Chinese J Modern Applied Pharm, 2009 (11): 946-8.
Storage conditions：Short-term storage at 2~8℃, long-term storage at -20 ~ -80℃
Shenshuai
Wenjing
Hedandan
