Celastrol

Name: Celastrol
Brand: Biopurify
Rating: 5 (1 reviews)

Catalogue No.： BP0327

CAS NO.: 34157-83-0

Purity: 98%

Brand: Biopurify

Botanical Source:

Celastrol is a pentacyclic triterpenoid that is 24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid bearing an oxo substituent at position 2, a hydroxy substituent at position 3 and two methyl groups at positions 9 and 13. An antioxidant and anti-inflammatory agent. Potently inhibits lipid peroxidation in mitochondria and inhibits TNF-alpha-induced NFB activation. Also shown to inhibit topoisomerase II activity in vitro (IC50 = 7.41 M). Celastrol is a potent proteasome inhibitor for the chymotrypsin-like activity of a purified 20S proteasome with IC50 of 2.5 μM. Celastrol is also a novel HSP90 inhibitor, it has anti-proliferative, anti-inflammatory, anti-tumor , antiangiogenesis, and antioxidant activities. Celastrol inhibits Plasmodium falciparum enoyl-acyl carrier protein reductase and inhibits VEGF receptors expression.

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BP0327-20mg	20mg	Sign in	Sign in
BP0327-100mg	100mg	Sign in	Sign in
BP0327-1000mg	1000mg	Sign in	Sign in

Contacts：400-829-7929，028-82633860，82633397，82633165

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Related diseases

Metabolic Syndrome Autoimmune disease Cancer Neurodegenerative disease Bacterial Infection (Methicillin-Resistant Staphylococcus aureus Infection)

Related targets

Metabolic Syndrome AMPK TNF PPARG NFKB1 NLRP3

Autoimmune disease TNF NFKB1 PTPN22 NLRP3 HLA-DRB1 CTLA4 IL2RA STAT4

Cancer AMPK TNF PPARG NFKB1 CASP3 BAX MTOR HSP90AA1

Neurodegenerative disease AMPK TNF PPARG NFKB1 CASP3 NLRP3 BAX MTOR HSP90AA1

Product description Related Products Prediction Parameters Reference Literature

Product name: Celastrol
Synonym name: Tripterin
Catalogue No.: BP0327
Cas No.: 34157-83-0
Formula: C₂₉H₃₈O₄
Mol Weight: 450.619
Botanical Source: Tripterygium wilfordii Hook.f.
Physical Description:
Type of Compound: Triterpenoids

Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle

Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.

The product could be supplied from milligrams to grams
Inquire for bulk scale.

Chengdu Biopurify Phytochemicals Ltd. is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine，TCM), Natural Active Pharmaceutical Ingredients worldwide.
The main services:
A. Supply active ingredients and reference standards of TCM, from mgs to kgs scale
B. Custom extraction and purification, target Herb Active Ingredients
C. Custom synthesis and semi-synthesis for Natural Active Ingredients
D. CR(contract research), CM(contract manufacture) and PD(process development) services from lab scale, pilot scale to commercial scale(GMP is also available)
E. TCM compounds library for drug screen,more than 3000 compounds available, many of them are rare and unique.