Camptothecin

Name: Camptothecin
Brand: Biopurify
Rating: 5 (1 reviews)

Catalogue No.： BP0308

CAS NO.: 7689-03-4

Purity: 98%

Brand: Biopurify

Botanical Source: Camptotheca acuminata.

Camptothecin is a pyranoindolizinoquinoline that is pyrano[3',4':6,7]indolizino[1,2-b]quinoline which is substituted by oxo groups at positions 3 and 14, and by an ethyl group and a hydroxy group at position 4 (the S enantiomer). It has a role as an antineoplastic agent, an EC 5.99.1.2 (DNA topoisomerase) inhibitor, a genotoxin and a plant metabolite. It is a delta-lactone, a quinoline alkaloid, a tertiary alcohol and a pyranoindolizinoquinoline. Camptothecin is a specific inhibitor of DNA topoisomerase I (Topo I) with IC50 of 0.68 μM; it is a novel alkaloidal leukemia and tumor inhibitor, is a strong inhibitor of nucleic acid synthesis in mammalian cells and a potent inducer of strand breaks in chromosomal DNA. Camptothecin and its analogs reduce amyloid-β production and amyloid-β42-induced IL-1β production.

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Related diseases

Colon cancer Ovarian cancer Acute Myeloid Leukemia Glioblastoma Small Cell Lung Cancer

Related targets

Colon cancer MCL1 ABCB1 TOP1 EGFR TP53 CASP3 CTNNB1 KRAS CDH1 VEGFA BAX CDKN1A PARP1 NFKBIA CDK1

Ovarian cancer ABCB1 TOP1 HIF1A EGFR TP53 CASP3 BRCA1 KRAS CDH1 VEGFA BAX CDKN1A PARP1 NFKBIA CDK1

Acute Myeloid Leukemia MCL1 ABCB1 TOP1 HIF1A EGFR TP53 CASP3 BAX CDKN1A PARP1 NFKBIA CDK1

Glioblastoma ABCB1 TOP1 HIF1A EGFR TP53 CASP3 VEGFA BAX MGMT CDK1

Small Cell Lung Cancer TOP1 EGFR TP53 CASP3 BRCA1 VEGFA BAX PARP1 CDK1

Product description Related Products Prediction Parameters Reference Literature

Product name: Camptothecin
Synonym name:
Catalogue No.: BP0308
Cas No.: 7689-03-4
Formula: C₂₀H₁₆N₂O₄
Mol Weight: 348.358
Botanical Source: Camptotheca acuminata.
Physical Description:
Type of Compound: Alkaloids

Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle

Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.

The product could be supplied from milligrams to grams
Inquire for bulk scale.

Chengdu Biopurify Phytochemicals Ltd. is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine，TCM), Natural Active Pharmaceutical Ingredients worldwide.
The main services:
A. Supply active ingredients and reference standards of TCM, from mgs to kgs scale
B. Custom extraction and purification, target Herb Active Ingredients
C. Custom synthesis and semi-synthesis for Natural Active Ingredients
D. CR(contract research), CM(contract manufacture) and PD(process development) services from lab scale, pilot scale to commercial scale(GMP is also available)
E. TCM compounds library for drug screen,more than 3000 compounds available, many of them are rare and unique.