Alpha-Mangostin

Catalogue No.： BP0155

CAS NO.: 6147-11-1

Purity: 98%

Brand: Phytopurify

Botanical Source: Garcinia mangostana L.

Alpha-mangostin is a member of the class of xanthones that is 9H-xanthene substituted by hydroxy group at positions 1, 3 and 6, a methoxy group at position 7, an oxo group at position 9 and prenyl groups at positions 2 and 8. Isolated from the stems of Cratoxylum cochinchinense, it exhibits antioxidant, antimicrobial and antitumour activities. It has a role as an antioxidant, an antimicrobial agent, an antineoplastic agent and a plant metabolite. Alpha-Mangostin has neuroprotective, anti-cancer, antifungal, neuroprotective, renoprotective, antioxidant and anti-inflammatory activities. Alpha-Mangostin exhibits peripheral and central antinociception through modulation of opioid and vanilloid receptors, the glutamatergic system, and the larginine/NO/cGMP/PKC/K(+)-ATP pathways; it suppresses phorbol 12-myristate 13-acetate-induced MMP-2/MMP-9 expressions via alphavbeta3 integrin/FAK/ERK and NF-kappaB signaling pathway in human lung adenocarcinoma A549 cells. Alpha-Mangostin is also a novel competitive histamine H1 receptor antagonist in smooth muscle cells. Alpha Mangostin is a dietary ketone with a wide range of biological activities, such as antioxidant, anti allergic, antiviral, antibacterial, anti-inflammatory, and anticancer effects. It is an inhibitor of the IDH1 mutant (IDH1-R132H) with a Ki value of 2.85 μ M.

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Related diseases

Alzheimer's Disease Endothelial dysfunction Inflammatory disease Non-small cell lung cancer Chronic Kidney Disease

Related targets

Alzheimer's Disease NOS3 APP PRKCA BCHE MAPK1 ESR1 NOS2 MMP9 NOS1 NFKB1 OPRM1 GRIN1

Endothelial dysfunction APP PRKCA MMP2 BCHE ESR1 CGAS TP53

Inflammatory disease NOS3 PRKCA TRPV1 MAPK1 NOS2 MMP9 NFKB1 HRH1

Non-small cell lung cancer PRKCA MMP2 MAPK1 NOS2 MMP9 TP53 NFKB1 HRH1

Chronic Kidney Disease NOS3 PRKCA NOS2 MMP9 NFKB1 HRH1 PRKG1

Product description Related Products Prediction Parameters Reference Literature

Synonym name: alpha-mangostin; Mangostin
Catalogue No.: BP0155
Cas No.: 6147-11-1
Formula: C₂₄H₂₆O₆
Mol Weight: 410.466
Botanical Source: Pigment from Garcinia mangostana

Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Can be supplied from milligrams to grams, up to kilograms.

Inquire for bulk scale.

Mangostin is a natural organic compound isolated from various parts of the mangosteen (Garcinia mangostana). It is a yellow crystalline solid with a xanthone core structure. Mangostin and a variety of other xanthones from mangosteen have been investigated for biological properties including antioxidant, anti-bacterial, anti-inflammatory, and anticancer activities.

References

(1) Matsumoto K, et al.Induction of apoptosis by xanthones from mangosteen in human leukemia cell lines. J Nat Prod 2003; 66(8):1124-1127.
(2) Suksamrarn S, et al. Xanthones from the green fruit hulls of Garcinia mangostana. J Nat Prod 2002; 65(5):761-763.
(3) Suksamrarn S, et al. Antimycobacterial activity of prenylated xanthones from the fruits of Garcinia mangostana. Chem Pharm Bull (Tokyo) 2003; 51(7):857-859.
(4) Gopalakrishnan G, Banumathi B, Suresh G. Evaluation of the antifungal activity of natural xanthones from Garcinia mangostana and their synthetic derivatives. J Nat Prod 1997; 60(5):519-524.
(5) Nakatani K, et al. Inhibition of cyclooxygenase and prostaglandin E2 synthesis by gamma-mangostin, a xanthone derivative in mangosteen,in C6 rat glioma cells. Biochem Pharmacol 2002; 63(1):73-79.
(6) Matsumoto K, et al. Preferential target is mitochondria in alpha-mangostin-induced apoptosis in human leukemia HL60 cells. Bioorg Med Chem 2004; 12(22):5799-5806.
(7) Williams P, et al. Mangostin inhibits the oxidative modification of human low density lipoprotein. Free Radic Res 1995; 23(2):175-184.
(8) Chairungsrilerd N, et al. Histaminergic and serotonergic receptor blocking substances from the medicinal plant Garcinia mangostana. Planta Med 1996; 62(5):471-472.
(9) Chen SX, Wan M, Loh BN. Active constituents against HIV-1 protease from Garcinia mangostana. Planta Med 1996; 62(4):381-382.
(10) Ho CK, Huang YL, Chen CC. Garcinone E, a xanthone derivative, has potent cytotoxic effect against hepatocellular carcinoma cell lines.Planta Med 2002; 68(11):975-979.
(11) Moongkarndi P, et al. Antiproliferation, antioxidation and induction of apoptosis by Garcinia mangostana (mangosteen) on SKBR3 human breast cancer cell line. J Ethnopharmacol 2004; 90(1):161-166.

HPLC of Alpha-Mangostin