Aloin A

Catalogue No.： BP0149

CAS NO.: 1415-73-2

Purity: 98%

Brand: Biopurify

Botanical Source: Sophora alopecuroides L

Aloin A is a C-glycosyl compound that is beta-D-glucopyranose in which the anomeric hydroxy group is replaced by a 4,5-dihydroxy-2-(hydroxymethyl)-10-oxo-9,10-dihydroanthracen-9-yl moiety (the 9S diastereoisomer). It has a role as a metabolite and a laxative. It is a C-glycosyl compound, a member of phenols, a cyclic ketone and a member of anthracenes. Aloe components (aloin, aloesin and aloe-gel) show anti-inflammatory effects, they can ameliorate intestinal inflammatory responses in a dextran sulfate sodium (DSS)-induced ulcerative colitis rat model. Aloin shows tyrosinase activity, it could be used as lightening agents in the treatment of hyperpigmentation disorders and cosmetic additives. Aloin is a potent proapoptotic agent, it showed a pronounced antiproliferative effect at physiological concentration (IC50 = 97 microM), caused cell cycle arrest in the S phase and markedly increased HeLaS3 cell apoptosis (to 24%). Aloin (Aloin-A; Barbaloin-A) is a natural anti-tumor anthraquinone glycoside with iron chelation activity. Aloin induces differentiation of MC3T3-E1 cells into osteoblasts through the MAPK mediated Wnt and Bmp signaling pathways. Alkaline phosphatase (ALP) is an early marker of osteoblast differentiation, and its activity is also enhanced by Aloin. Aloin can alleviate brain edema, reduce blood-brain barrier damage, and improve cortical shock injury. Aloin can be used for research on osteoporosis and traumatic brain injury (TBI).

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Related diseases

Hyperglycemia Osteoporosis Cervical cancer Ulcerative Colitis Hyperpigmentation Disorder

Related targets

Hyperglycemia ALOX15 AKR1B1 P4HB MAPK1 EPHX2 NOS2 HKDC1

Osteoporosis BCL2 AKR1B1 RELA MAPK1 TNF NOS2 PTGS2 IL6 IL1B RUNX2 BMP2

Cervical cancer BCL2 MAPK1 CASP9 PTGS2 CDK2 CASP3 BAX

Ulcerative Colitis RELA TNF NOS2 PTGS2 IL6 IL1B

Hyperpigmentation Disorder TYR MITF

Product description Related Products Prediction Parameters Reference Literature

Synonym name: Barbaloin A
Catalogue No.: BP0149
Cas No.: 1415-73-2
Formula: C₂₁H₂₂O₉
Mol Weight: 418.398
Botanical Source: various Aloe spp.

Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Can be supplied from milligrams to grams.

For Reference Standard and R&D, Not for Human Use Directly.
Inquire for bulk scale.