8-O-Acetyl shanzhiside methyl ester

Name: 8-O-Acetyl shanzhiside methyl ester
Brand: Biopurify
Rating: 5 (1 reviews)

Catalogue No.： BP0110

CAS NO.: 57420-46-9

Purity: 98%

Brand: Biopurify

Botanical Source:

8-O-Acetyl shanzhiside methyl ester is a cyclosporin glucoside isolated from folk medicinal plants in Xizang, China. 8-O-Acetyl shanzhiside methyl ester can inhibit NF - κ B activity.

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BP0110-20mg	20mg	Sign in	Sign in
BP0110-100mg	100mg	Sign in	Sign in

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Related diseases

Inflammatory Bowel Disease Rheumatoid arthritis Nephritis Acute Lung Injury/Acute Respiratory Distress Syndrome

Related targets

Inflammatory Bowel Disease STAT3 RELA TNF NOS2 PTGS2 IL6 IL1B ICAM1 CXCL8 HMGB1 NFKBIA

Rheumatoid arthritis STAT3 RELA TNF NOS2 PTGS2 IL6 IL1B ICAM1 CXCL8 HMGB1 NFKBIA

Nephritis STAT3 SELP TNF LGALS8 LGALS3 LGALS9 PTGS2 IL6 IL1B

Acute Lung Injury/Acute Respiratory Distress Syndrome RELA TNF NOS2 PTGS2 IL6 IL1B ICAM1 CXCL8 HMGB1 NFKBIA

Product description Related Products Prediction Parameters Reference Literature

Product name: 8-O-Acetyl shanzhiside methyl ester
Synonym name: Barlerin; Umbroside
Catalogue No.: BP0110
Cas No.: 57420-46-9
Formula: C₁₉H₂₈O₁₂
Mol Weight: 448.421
Botanical Source: Barleria prionitis
Physical Description: Powder
Type of Compound: Iridoids

Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle

Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.

The product could be supplied from milligrams to grams, up to kilograms
Inquire for bulk scale.

Descriptions:
8-O-acetyl shanzhiside methylester (ND01), an iridoid glucoside compound, was isolated from the leaves of Lamiophlomis rotata (Benth.) Kudo, ND01 has potential against cerebral ischemic injury, and its protective effect on oxygen–glucose deprivation-induced injury might be due to the suppression of intracellular Ca 2+ elevation and caspase-3 activity, and improvement of mitochondrial energy metabolism.[1]
8- O -acetyl Shanzhiside Methylester can increases angiogenesis and improve functional recovery after stroke.[2]
8-O-acetyl shanzhiside methylester has protective effects on experimental myocardial ischemia injury, the effects might be due to block of myocardial inflammatory cascades through an HMGB1-dependent NF-κB signaling pathway.[3]
8-O-acetyl shanzhiside methylester protects diabetic brain against I/R injury by alleviating diabetic cerebral I/R injury and attenuating blood–brain barrier (BBB) breakdown, and its protective effects may involve HMGB-1 and NF-κB signalling pathway.[4]

References:
[1] Jiang W L, Fu F H, Zheng S G, et al. Eur J Pharmacol, 2010, 629(629):20-4.
[2] Jiang W L, Zhang S P, Zhu H B, et al. Basic Clin Pharmacol , 2011, 108(1):21-7.
[3] Kang Z C, Jiang W L, Xu Y, et al. Eur J Pharm Sci Official J Eur Federat Pharml Sci, 2012, 47(1):124-30.
[4] Zhang L, Kan Z C, Zhang X L, et al. Basic Clin Pharmacol , 2014, 115(6):481–7.
[5] Liao L D, Tang C, Sheng-Ming L U, et al. Res Practi on Chinese Med, 2011(05):70-2.