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Product name: 5-Hydroxy-6,7-dimethoxylflavone
Synonym name: 5-Hydroxy-6,7-dimethoxyflavone; Mosloflavone
Catalogue No.: BP0086
Cas No.: 740-33-0
Formula: C17H14O5
Mol Weight: 298.294
Botanical Source: Crotalaria pallida Ait.
Physical Description:
Type of Compound: Flavonoids
Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
The product could be supplied from milligrams to grams
Inquire for bulk scale.
Chengdu Biopurify Phytochemicals Ltd. is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine，TCM), Natural Active Pharmaceutical Ingredients worldwide.
The main services:
A. Supply active ingredients and reference standards of TCM, from mgs to kgs scale
B. Custom extraction and purification, target Herb Active Ingredients
C. Custom synthesis and semi-synthesis for Natural Active Ingredients
D. CR(contract research), CM(contract manufacture) and PD(process development) services from lab scale, pilot scale to commercial scale(GMP is also available)
E. TCM compounds library for drug screen,more than 3000 compounds available, many of them are rare and unique.
HPLC of Mosloflavone
Storage conditions：Short-term storage at 2~8℃, long-term storage at -20 ~ -80℃
83.8300
2.3000
2.3000
Low
No
No
No
No
No
No
Mosloflavone (CAS No.: 740-33-0) is a naturally occurring flavonoid compound belonging to the 2-hydroxyflavanone class and exhibits significant biological activity. As one of the important active ingredients in Scutellaria baicalensis, shepherd's purse flavonoids have attracted widespread attention due to their diverse pharmacological effects, especially showing excellent potential in antiviral, anti-inflammatory, and antibacterial fields. In recent years, with in-depth research into viral infection mechanisms and inflammatory response regulation, the role of shepherd's purse flavonoids in combating enterovirus 71 (EV71) infection, inhibiting inflammatory factor expression, and regulating immune responses has gradually been revealed. In addition, its toxicity and inhibition of biofilm formation against Pseudomonas aeruginosa also provide a theoretical basis for its development as a novel fungicide. This paper will systematically review the chemical structure, sources, pharmacological activity, mechanism of action, druggability evaluation, and clinical application prospects of coherine flavonoids, aiming to provide references for pharmacological research of natural products and new drug development.
Fragrant purse flavonoids are a typical flavonoid ether with a molecular formula of C_17H_14O_6 and a molecular weight of 302.29. Its chemical structure features hydroxyl and methoxy substituents on the flavanone backbone, specifically the 2-hydroxyflavanone structure, which gives it strong free radical scavenging ability and bioactivity. In terms of physicochemical properties, the LogP value of cameloid flavonoids is 2.3, indicating moderate lipid solubility, which is beneficial for cell membrane penetration and bioavailability. Its topological pole surface area (TPSA) is 83.83 Ų, and it has 5 hydrogen bond acceptors, indicating good affinity for binding to biomacromolecules. It has low blood-brain barrier permeability, low risks of hepatotoxicity and cardiotoxicity, and lacks hERG channel inhibition and Ames-induced mutagenicity, demonstrating good safety and drug potential.
Shepherd's purse flavonoids are mainly isolated from the traditional Chinese medicinal herb Scutellaria baicalensis. Scutellaria scutellaria is a plant in the Lamiaceae family, and its roots are rich in flavonoids. As one of the active monomers, the content of Flavonoids in Scutellaria baileycalensis is relatively stable. Traditional extraction methods usually use alcohol solvents (such as methanol, ethanol) for extraction and combine liquid-liquid separation, column chromatography, and other separation and purification techniques to obtain high-purity shepherd's purbinoids. In recent years, the application of ultrasound-assisted extraction, microwave-assisted extraction, and high-performance liquid chromatography (HPLC) technology has improved extraction efficiency and purity, meeting the needs of pharmacological research and formulation development.
Research on shepherd's purse flavonoids has been particularly outstanding in the antiviral field, particularly targeting the inhibitory effects of enterovirus 71 (EV71). EV71 is a major pathogen causing hand, foot, and mouth disease and severe neurological complications, with limited available treatment options. Research shows that shepherd's purse flavonoids can significantly inhibit viral replication during the early stages of viral infection, reducing the formation of cytopathic effects (CPE). Its mechanism involves inhibiting the expression of the viral VP2 protein, blocking the synthesis of viral capsid proteins, thereby hindering viral assembly and transmission. This discovery provides a new molecular basis for the development of anti-EV71 drugs.
Fraternoid flavonoids demonstrate good anti-inflammatory effects by regulating the expression of inflammatory mediators. In vitro experiments showed that it exhibited dose-dependent inhibitory effects on TNF-β, IL-1β, and induced nitric oxide synthase (iNOS) levels in the supernatant of the mouse macrophage line J774A. Its IC50 values were 16.4 μM (TNF-β) and 6.4 μM (IL-1β), demonstrating high inhibition efficiency. By inhibiting these key inflammatory factors, shepherd's purse flavonoids are expected to play a role in the treatment of inflammatory diseases and immunomodulatory-related conditions.
As a promising natural fungicide, Fraxanthoid showed significant toxic inhibition against Pseudomonas aeruginosa. Pseudomonas aeruginosa is a common multidrug-resistant pathogen in clinical practice, and its biofilm formation is a key factor making the infection difficult to cure. Fraconoid not only inhibits the formation of biofilms but also reduces the expression of virulence factors in bacteria, demonstrating potential application value.
The multi-target mechanism of fraxinoidoides forms the basis of their broad pharmacological activity. In terms of antiviral effects, it mainly targets the VP2 protein of the EV71 virus, blocking the synthesis of viral capsid proteins and inhibiting viral replication. Anti-inflammatory effects work by downregulating the expression of pro-inflammatory cytokines TNF-β and IL-1β, inhibiting iNOS activity, reducing the release of inflammatory mediators, and alleviating inflammatory responses.
In addition, shepherd's purse flavonoids have potential interactions with various molecular targets associated with heart failure, including AMPK (PRKAA1), EHMT2, APP, PTPN1, MAOA, ESR2, ABCB1, ALOX15, ABCG2, and FEN1. These targets involve multiple signaling pathways, including energy metabolism, epigenetic regulation, neuroprotection, inflammatory responses, and drug transport, suggesting that shepherd's purse flavonoids may play multiple regulatory roles in the treatment of cardiovascular diseases, especially heart failure.
The druggability parameters of shepherd's purse flavonoids indicate that they have promising potential for drug development. Its molecular weight is moderate, lipid solubility is suitable for cell membrane penetration, and the number of TPSA and hydrogen bond receptors falls within the ideal range for most oral drugs. Low blood-brain barrier permeability, reducing the risk of central nervous system toxicity. The risk of hepatotoxicity and cardiotoxicity is low, and there is no hERG channel inhibition or mutagenicity, making it relatively safe.
Although pharmacokinetic studies on shepherd's purse flavonoids are currently limited, existing data indicate good oral absorption, metabolism mainly occurs through hepatic enzyme systems, and the activity and excretion pathways of these metabolites still require further clarification. Future research should focus on systematic evaluation of its in vivo kinetic characteristics, metabolic stability, and bioavailability to promote its clinical translation.
With its multi-target and multifunctional pharmacological properties, shepherd's purse flavonoids show broad application prospects in antiviral, anti-inflammatory, and antibacterial fields. Especially in the prevention and treatment of EV71 virus infection, shepherd's purse flavonoids, as a natural antiviral candidate, have significant clinical development value. Its anti-inflammatory effects offer new ideas for treating chronic inflammatory diseases and immune regulation disorders. At the same time, as a novel antimicrobial, the inhibitory effect of shepherd's purification flavonoids against multidrug-resistant strains makes it possible for antibiotic substitution or adjunctive therapy.
In the future, clinical application of shepherd's purse flavonoids will rely on systematic pharmacokinetics, safety evaluation, and clinical trial validation. By integrating modern drug design techniques and optimizing their structure to enhance activity and pharmacokinetic performance, they will further advance its emergence as a natural medicine available for clinical use. Moreover, based on its multi-target mechanism of action, the potential therapeutic value of shepherd's purification flavonoids in complex diseases such as heart failure is also worth further exploration.
As a natural flavonoid derived from Scutellaria baicalensis, Shepherd's Purple has attracted much attention for its remarkable antiviral, anti-inflammatory, and antibacterial activities. Its unique chemical structure endows it with excellent bioactivity and druggability, and its mechanism of action involves multiple molecular targets, demonstrating the advantages of multi-target pharmacology of natural products. Although current research mainly focuses on in vitro and animal models, the clinical translation of shepherd's purse flavonoids still faces certain challenges, but their potential as novel natural drug lead compounds cannot be ignored. In the future, through multidisciplinary collaboration, in-depth analysis of its mechanisms of action and pharmacokinetic characteristics is expected to promote the clinical application of cameloid flavonoids in antiviral, anti-inflammatory, and antibacterial fields, benefiting patients.
Shenshuai
Wenjing
Hedandan
