Neochlorogenic acid

Catalogue No.： BP0083

CAS NO.: 906-33-2

Purity: 98%

Brand: Phytopurify

Botanical Source: Lonicera japonica Thunb.

Trans-5-O-caffeoyl-D-quinic acid is a cinnamate ester obtained by formal condensation of the carboxy group of trans-caffeic acid with the 5-hydroxy group of quinic acid. It has a role as a plant metabolite. It is a cinnamate ester and a cyclitol carboxylic acid. It is functionally related to a trans-caffeic acid and a (-)-quinic acid. It is a conjugate acid of a trans-5-O-caffeoyl-D-quinate. Neochlorogenic acid shows antioxidant, antibacterial, antiviral, and antipyretic activities and exerts neuroprotective effects through the inhibition of pro-inflammatory pathways in activated microglia. Neochlorogenic acid is a natural polyphenolic compound found in dried fruits and other plants. Neochlorogenic acid inhibits the production of TNF - α and IL-1 β. Neochlorogenic acid inhibits the expression of iNOS and COX-2 proteins. Neochlorogenic acid also inhibits the activation of phosphorylated NF - κ B p65 and p38 MAPK.

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Related diseases

Atherosclerosis Alzheimer's Disease Type 2 Diabetes Mellitus Non-alcoholic fatty liver disease Obstructive sleep apnea

Related targets

Atherosclerosis PTPN1 RELA TNF NOS2 PPARG PTGS2 IL6 IL1B LDLR ICAM1 VCAM1 PPARA

Alzheimer's Disease PTPN1 APP RELA TNF NOS2 PPARG PTGS2 IL6 IL1B

Type 2 Diabetes Mellitus PTPN1 APP MGAM RELA TNF NOS2 PPARG PTGS2 IL6 IL1B PPARA

Non-alcoholic fatty liver disease PTPN1 RELA TNF NOS2 PPARG PTGS2 IL6 IL1B PPARA

Obstructive sleep apnea APP CA4 CA7 CA14 CA5B PTGS2

Product description Related Products Prediction Parameters Reference Literature

Product name: Neochlorogenic acid
Synonym name: Caffeoylquinic acid
Catalogue No.: BP0083
Cas No.: 906-33-2
Formula: C₁₆H₁₈O₉
Mol Weight: 354.311
Botanical Source:
Physical Description: Powder
Type of Compound: Phenylpropanoids

Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle

Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.

The product could be supplied from milligrams to grams, up to kilograms
Inquire for bulk scale.

Descriptions:
Neochlorogenic acid (NCA) is a natural polyphenolic compound found in dried fruits and other plants, has shown that phenolic acids including NCA have outstanding antioxidant, antibacterial, antiviral, and antipyretic activities, it also exerts neuroprotective effects through the inhibition of pro-inflammatory pathways in activated microglia.[1]
Neochlorogenic acid (NCGA), chlorogenic acid (CGA) and its isomer, were found to be the major phenolic compounds in the flesh and peel of three peach cultivars, the high concentrations of CGA and NGA in immature fruits might contribute to their reduced susceptibility or increased resistance to brown rot infection by interfering with fungal melanin production.[2]
Neochlorogenic acid and chlorogenic acid could be colon cancer suppressive components of the prune.[3]

References:
[1] Kim M, Choi S Y, Lee P, et al. Neurochem Res, 2015, 40(9):1792-8.
[2] Villarino M, Sandín-Espa?a P, Melgarejo P, et al. J Agr Food Chem, 2011, 59(7):3205-13.
[3] Lee S O, Thurow T, Rom C R, et al. UARKive, 2012,5.
[4] Bing H E, Yang S Y, Yan Z. J Chinese Pharm Sci, 2012, 47(16):1280-4.