| 产品名称 | AKT1-Specific Recombinant antibody |
|---|---|
| 产品编号 | HB50288 |
| Uniprot ID | P31749 |
| Host Species | Rabbit |
| Reactivity | human, mouse |
| Tested Applications | IHC |
| Application | IHC :1:100 -1:200 |
| Background | AKT is a serine/threonine kinase and it participates in the key role of the PI3K signaling pathway. Phosphatidylinositol-3 kinase (PI3K) is the key regulator of AKT activation. The recruitment of inactive AKT protein to PIP3-rich areas of the plasma membrane results in a conformational change that exposes the activation loop of AKT. AKT's activating kinase, phosphoinositide-dependent protein kinase (PDK1) , is also recruited to PIP3 microdomains. PDK1 phosphorylates AKT on threonine 308 (Thr308) of the exposed activation loop, activating AKT and leading to a second phosphorylation of AKT at serine 473 (Ser473) by a kinase presumed to be mTORC2 that further potentiates kinase activity. Active AKT will phosphorylate various downstream protein targets that control cell growth and translational control and act to suppress apoptosis. (PMID: 31594388, PMID: 30808672). 80457-1-RR specifically recognizes AKT1. |
| Alternative Names | AKT1 (C-terminal), AKT, AKT 1, AKT1, 4I5 |
| Immunogen | Peptide |
| Subcellular Localization | Cytoplasm |
| Conjugate | Unconjugated |
| Purification | Protein A purification |
| Formulation | Liquid |
| Storage | Store at -20°C |
| Figure ID 1 | PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%. |
| Figure ID 2 | HB50288 |
| 保质期 | 12 months |
