| 产品名称 | AMACR Recombinant antibody |
|---|---|
| 产品编号 | HB50091 |
| Uniprot ID | Q9UHK6 |
| Host Species | Rabbit |
| Reactivity | Human |
| Tested Applications | IHC |
| Application | IHC :1:100 -1:200 |
| Background | AMACR(Alpha-methyl acyl-CoA racemase) belongs to the CaiB/BaiF CoA-transferase family. It is a mitochondrial and peroxisomal enzyme that catalyzes the conversion of 2R stereoisomers of phytanic and pristanic acid to their S counterparts. AMACR has previously been shown to be a highly sensitive marker for colorectal and clinically localized prostate cancer (PCa). However, AMACR expression is down-regulated at the transcript and protein level in hormone-refractory metastatic PCa, suggesting a hormone-dependent expression of AMACR(PMID:12213712). It has 3 isoforms produced by alternative splicing and it can form a dimer of 70-75 kDa(PMID:21812041). Defects in AMACR are the cause of alpha-methyl acyl-CoA racemase deficiency (AMACRD) and congenital bile acid synthesis defect type 4 (CBAS4). |
| Alternative Names | AMACR, p504S, 242456D1, 2-methylacyl-CoA racemase, Alpha-methylacyl-CoA racemase |
| Immunogen | Recombinant Protein |
| Subcellular Localization | Cytoplasm |
| Isotype | IgG |
| Conjugate | Unconjugated |
| Purification | ProA affinity purified IgG |
| Formulation | Liquid |
| Storage | Store at -20°C |
| Figure ID 1 | PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%. |
| Figure ID 2 | HB50091 |
| 曾用货号 | B32128R |
| 保质期 | 12 months |
