| 产品名称 | VDAC1/Porin Monoclonal antibody |
|---|---|
| 产品编号 | HB30039 |
| Uniprot ID | P21796 |
| Host Species | Mouse |
| Reactivity | human, mouse, rat, pig |
| Tested Applications | WB, IF-P, FC (Intra), ELISA |
| Application | WB : 1:5000-1:50000 IF-P : 1:200-1:800 FC (INTRA) : 0.80 ug per 10^6 cells in a 100 µl suspension |
| Background | VDAC1, also named as VDAC, porin 31HM, porin 31HL and plasmalemmal porin, belongs to the eukaryotic mitochondrial porin family. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV, to form a channel through the mitochondrial outer membrane and also the plasma membrane. Unlike other membrane transport proteins, porins are large enough to allow passive diffusion. Studies have shown that VDAC1 is subject to both phosphorylation and acetylation (PMID: 23233904). The apparent molecular weight of VDAC1 is 30-37 kDa (PMID: 14573604; 23754752; 25681439). Hypoxic conditions were found to trigger cleavage of the VDAC1 C-terminal to yield a 26-kDa truncated but active form (PMID: 22389449; 23233904). |
| Alternative Names | Porin, VDAC1, 1E2C7, hVDAC1, Plasmalemmal porin |
| Immunogen | Peptide |
| Calculated MW | 31 kDa |
| Observed mw | 35-37 kDa |
| Subcellular Localization | Mitochondria |
| Isotype | IgG3 |
| Conjugate | Unconjugated |
| Purification | Protein A purification |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Formulation | Liquid |
| Storage | Store at -20°C |
| Figure ID 2 | HB30039 |
| 保质期 | 12 months |
