| 中文名称 |
Rabbit polyclonal anti-R Cdk4 antibody (C-term) |
| 英文名称 |
Rabbit polyclonal anti-R Cdk4 antibody (C-term) |
| 灵敏度 |
Rat |
| 免疫原 |
This Rat Cdk4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 272-303 amino acids from the C-terminal region of rat Cdk4. |
| 应用范围 |
WB |
| 克隆性 |
Polyclonal |
| 物种 |
Rabbit |
| 储存条件 |
Store at -20°C as received. |
Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).
经理
张廷冬
周燚
谭红飞
李东
罗忠兰
