| 中文名称 |
Mouse monoclonal anti-TP53 antibody (N-term) |
| 英文名称 |
Mouse monoclonal anti-TP53 antibody (N-term) |
| 灵敏度 |
Human |
| 免疫原 |
Purified His-tagged TP53 protein was used to produced this monoclonal antibody. |
| 应用范围 |
WB |
| 克隆性 |
Monoclonal |
| 物种 |
Mouse |
| 储存条件 |
Store at -20°C as received. |
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.
经理
张廷冬
周燚
谭红飞
李东
罗忠兰
